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One-hour postload plasma glucose concentration in people with normal glucose homeostasis predicts future diabetes mellitus: a 12-year community-based cohort study

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dc.contributor.authorOh, TJ-
dc.contributor.authorLim, S-
dc.contributor.authorKim, KM-
dc.contributor.authorMoon, JH-
dc.contributor.authorChoi, SH-
dc.contributor.authorCho, YM-
dc.contributor.authorPark, KS-
dc.contributor.authorJang, H-
dc.contributor.authorCho, NH-
dc.date.accessioned2018-07-27T00:52:12Z-
dc.date.available2018-07-27T00:52:12Z-
dc.date.issued2017-
dc.identifier.issn0300-0664-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/15585-
dc.description.abstractOBJECTIVE: In Caucasians, plasma glucose concentration at 1 h during an oral glucose tolerance test (OGTT) may be a better predictor of future diabetes mellitus than the fasting or 2-h postload glucose concentration. We investigated whether the 1-h glucose concentration could be used to predict future diabetes mellitus in Asian ethnicity.
MEASUREMENTS: A total of 5703 Koreans with normal glucose tolerance were enrolled from the Korean Genome and Epidemiology Study. Indices of insulin sensitivity and beta-cell function estimated from standard 75-g OGTTs performed every 2 years for 12 years were used to identify whether the 1-h glucose concentration could predict future diabetes mellitus.
RESULTS: The mean age and body mass index at baseline were 51.3 +/- 8.7 years and 24.2 +/- 3.0 kg/m(2) , respectively. During the 12-year follow-up, 593 subjects (10.3%) developed diabetes mellitus. The area under the receiver-operating characteristic curve for incident diabetes mellitus was higher for the 1-h postload glucose concentration than for the fasting or postload 2-h glucose concentration (0.74 vs 0.61 or 0.63). The cut-off value of >/=8.0 mmol/l identified incident diabetes mellitus with 70% sensitivity and 68% specificity. After adjusting for typical risk factors, subjects with a 1-h postload glucose concentration >/=8.0 mmol/l had lower beta-cell function and a 2.84-fold increased risk of incident diabetes mellitus compared with their counterparts.
CONCLUSIONS: In this community-based 12-year prospective cohort study, 1-h postload plasma glucose concentration was an independent predictor of future diabetes mellitus and 8.0 mmol/l was suggested as a cut-off value.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAsian Continental Ancestry Group-
dc.subject.MESHBlood Glucose-
dc.subject.MESHCohort Studies-
dc.subject.MESHDiabetes Mellitus, Type 2-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHGlucose Tolerance Test-
dc.subject.MESHHomeostasis-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHProspective Studies-
dc.titleOne-hour postload plasma glucose concentration in people with normal glucose homeostasis predicts future diabetes mellitus: a 12-year community-based cohort study-
dc.typeArticle-
dc.identifier.pmid27859511-
dc.contributor.affiliatedAuthor조, 남한-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/cen.13280-
dc.citation.titleClinical endocrinology-
dc.citation.volume86-
dc.citation.number4-
dc.citation.date2017-
dc.citation.startPage513-
dc.citation.endPage519-
dc.identifier.bibliographicCitationClinical endocrinology, 86(4). : 513-519, 2017-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1365-2265-
dc.relation.journalidJ003000664-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Preventive Medicine & Public Health
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