Cited 0 times in Scipus Cited Count

Clinical characteristics of late-onset neuromyelitis optica spectrum disorder: A multicenter retrospective study in Korea

Seok, JM | Cho, HJ | Ahn, SW | Cho, EB | Park, MS | Joo, IS  | Shin, HY | Kim, SY | Kim, BJ | Kim, JK | Cho, JY | Huh, SY | Kwon, O | Lee, KH | Kim, BJ | Min, JH
Multiple sclerosis (Houndmills, Basingstoke, England), 23(13). : 1748-1756, 2017
Journal Title
Multiple sclerosis (Houndmills, Basingstoke, England)
BACKGROUND: There are currently few studies regarding late-onset neuromyelitis optica spectrum disorder (LO-NMOSD).
OBJECTIVE: We aimed to describe the characteristic features of patients with LO-NMOSD in Korea.
METHODS: Anti-aquaporin-4 antibody-positive patients with neuromyelitis optica spectrum disorder (NMOSD) from nine tertiary hospitals were reviewed retrospectively. The patients were divided into two groups based on age of onset: LO-NMOSD (50 years of age at onset) versus early-onset neuromyelitis optica spectrum disorder (EO-NMOSD) (<50 years of age at onset). Clinical, laboratory, and magnetic resonance imaging (MRI) parameters were investigated.
RESULTS: Among a total of 147 patients (125 female: age of onset, 39.4 +/- 15.2 years), 45 patients (30.6%) had an age of onset of more than 50 years. Compared to patients with EO-NMOSD, patients with LO-NMOSD had more frequent isolated spinal cord involvement at onset (64.4% vs 37.2%, p = 0.002), less frequent involvement of the optic nerve (40.0% vs 67.7%, p = 0.002), and less frequent brain MRI lesions (31.1% vs 50.0%, p = 0.034). Furthermore, there was a significant positive correlation between age of onset and Expanded Disability Status Scale (EDSS) score at last follow-up ( r = 0.246, p = 0.003).
CONCLUSION: Age of onset could be an important predictor of lesion location and clinical course of patients with NMOSD.

Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
Ajou Authors
주, 인수
Files in This Item:
There are no files associated with this item.


해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.