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Clinical characteristics and prognostic inflection points among long-term survivors of advanced epithelial ovarian cancer

Authors
Son, JH  | Kong, TW  | Paek, J  | Song, KH | Chang, SJ  | Ryu, HS
Citation
International journal of gynaecology and obstetrics, 139(3). : 352-357, 2017
Journal Title
International journal of gynaecology and obstetrics
ISSN
0020-72921879-3479
Abstract
OBJECTIVE: To assess clinical characteristics of long-term survivors of advanced epithelial ovarian cancer (EOC) to define a prognostic inflection point for long-term survival.
METHODS: A retrospective analysis was undertaken of patients with FIGO stage III or IV EOC treated at one center in South Korea from 2000 to 2012. Patients who survived 5 years or more were identified, and the periods of disease-free survival and overall survival were evaluated for prognostic inflection points to indicate long-term survival. Clinicopathologic data and treatment-associated factors were assessed.
RESULTS: In total, 60 patients survived more than 5 years. Thirty-three (55%) patients experienced disease recurrence and 11 (18%) died due to advanced EOC during a median follow-up period of 92 months (range 61-205). Most recurrence events (32/33, 97%) and deaths (10/11, 91%) occurred within 6 years and 8 years, respectively. Although half the long-term (>8 year) survivors with stage IIIC-IV disease experienced disease recurrence, they had a significantly longer platinum-free interval (P=0.007) and tended to have received aggressive surgical treatments after disease recurrence (P=0.054), as compared with survivors for 5-8 years.
CONCLUSION: Survival for 8 years might represent a prognostic inflection point for long-term survival in advanced EOC.
Keywords
DOI
10.1002/ijgo.12315
PMID
28857180
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
Ajou Authors
공, 태욱  |  백, 지흠  |  손, 주혁  |  유, 희석  |  장, 석준
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