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Intravoxel incoherent motion diffusion-weighted magnetic resonance imaging of focal vertebral bone marrow lesions: initial experience of the differentiation of nodular hyperplastic hematopoietic bone marrow from malignant lesions

DC Field Value Language
dc.contributor.authorPark, S-
dc.contributor.authorKwack, KS-
dc.contributor.authorChung, NS-
dc.contributor.authorHwang, J-
dc.contributor.authorLee, HY-
dc.contributor.authorKim, JH-
dc.date.accessioned2018-08-24T01:48:21Z-
dc.date.available2018-08-24T01:48:21Z-
dc.date.issued2017-
dc.identifier.issn0364-2348-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/15830-
dc.description.abstractOBJECTIVE: To evaluate the ability of intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (MRI) parameters to differentiate nodular hyperplastic hematopoietic bone marrow (HHBM) from malignant vertebral bone marrow lesions (VBMLs).
MATERIALS AND METHODS: A total of 33 patients with 58 VBMLs, including 9 nodular HHBM lesions, 39 bone metastases, and 10 myelomas, were retrospectively assessed. All diagnoses were confirmed either pathologically or via image assessment. IVIM diffusion-weighted MRI with 11 b values (from 0 to 800 s/mm(2)) were obtained using a 3.0-T MR imager. The apparent diffusion coefficient (ADC), pure diffusion coefficient (D), perfusion fraction (f), and pseudodiffusion coefficient (D*) were calculated. ADC and IVIM parameters were compared using the Mann-Whitney U test. Receiver operating characteristic (ROC) curve analysis was performed to assess the diagnostic performances of ADC, D, f, and D* in terms of VBML characterization. The diagnostic performance of morphological MR sequences was also assessed for comparison.
RESULTS: The ADC and D values of nodular HHBM were significantly lower than those of malignant VBML (both p values < 0.001), whereas the f value was significantly higher (p < 0.001). However, there were no significant differences in D* between the two groups (p = 0.688). On ROC analysis, the area under the curve (AUC) for D was 1.000, which was significantly larger than that for ADC (AUC = 0.902).
CONCLUSION: Intravoxel incoherent motion diffusion-weighted MRI can be used to differentiate between nodular HHBM and malignant VBML. The D value was significantly lower for nodular HHBM, and afforded a better diagnostic performance than the ADC, f, and D* values in terms of such differentiation.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBone Marrow/diagnostic imaging-
dc.subject.MESHBone Marrow Diseases/diagnostic imaging-
dc.subject.MESHBone Marrow Neoplasms/diagnostic imaging-
dc.subject.MESHDiagnosis, Differential-
dc.subject.MESHDiffusion Magnetic Resonance Imaging/methods-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHSpinal Neoplasms/diagnostic imaging-
dc.subject.MESHSpine/diagnostic imaging-
dc.titleIntravoxel incoherent motion diffusion-weighted magnetic resonance imaging of focal vertebral bone marrow lesions: initial experience of the differentiation of nodular hyperplastic hematopoietic bone marrow from malignant lesions-
dc.typeArticle-
dc.identifier.pmid28265697-
dc.contributor.affiliatedAuthor박, 성훈-
dc.contributor.affiliatedAuthor곽, 규성-
dc.contributor.affiliatedAuthor정, 남수-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s00256-017-2603-z-
dc.citation.titleSkeletal radiology-
dc.citation.volume46-
dc.citation.number5-
dc.citation.date2017-
dc.citation.startPage675-
dc.citation.endPage683-
dc.identifier.bibliographicCitationSkeletal radiology, 46(5). : 675-683, 2017-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1432-2161-
dc.relation.journalidJ003642348-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
Journal Papers > School of Medicine / Graduate School of Medicine > Orthopedic Surgery
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