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PD-L1 expression correlates with VEGF and microvessel density in patients with uniformly treated classical Hodgkin lymphoma

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dc.contributor.authorKoh, YW-
dc.contributor.authorHan, JH-
dc.contributor.authorYoon, DH-
dc.contributor.authorSuh, C-
dc.contributor.authorHuh, J-
dc.date.accessioned2018-08-24T01:48:22Z-
dc.date.available2018-08-24T01:48:22Z-
dc.date.issued2017-
dc.identifier.issn0939-5555-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/15834-
dc.description.abstractRecent studies have reported the associations between programmed death-ligand 1 (PD-L1) or PD-L2/PD-1 pathways and pro-angiogenic genes including hypoxia-inducible factors (HIFs) and vascular endothelial growth factor (VEGF) in several malignancies. However, no study has examined the relationship or prognostic implication of PD-L1, PD-L2, PD-1, VEGF expression, and microvessel density (MVD) in classical Hodgkin lymphoma (cHL) patients. Diagnostic tissues from 109 patients with doxorubicin, bleomycin, vinblastine, and dacarbazine-treated cHL were evaluated retrospectively by immunohistochemical analysis for PD-L1, PD-L2, PD-1, VEGF expression, and for CD31 expression as a measure of MVD. There was a positive correlation between PD-L1 and VEGF expression (P = 0.008) and additionally between PD-L2 and VEGF expression (P = 0.001). The mean MVD in tumors positive for both PD-L1 and VEGF was significantly (P = 0.022) higher than the mean MVD in tumors negative for both markers. High PD-1 expression group had lower (P = 0.019) 5-year overall survival rate than low PD-1 expression group. Multivariate analysis revealed that PD-1 was an independent prognostic factor for cHL with significance (P = 0.026). However, PD-L1, PD-L2, and VEGF expression had no prognostic impact. Our data confirmed the positive correlations between PD-L1, VEGF, or MVD. Our findings provided evidence supporting new therapeutic approaches including combinations of anti-PD-L1/PD-1 and anti-VEGF therapy in addition to the current standard regimen for cHL.-
dc.language.isoen-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols-
dc.subject.MESHB7-H1 Antigen-
dc.subject.MESHBiomarkers, Tumor-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHGene Expression Regulation, Neoplastic-
dc.subject.MESHHodgkin Disease-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMicrovessels-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeovascularization, Pathologic-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHVascular Endothelial Growth Factor A-
dc.subject.MESHYoung Adult-
dc.titlePD-L1 expression correlates with VEGF and microvessel density in patients with uniformly treated classical Hodgkin lymphoma-
dc.typeArticle-
dc.identifier.pmid28842748-
dc.contributor.affiliatedAuthor고, 영화-
dc.contributor.affiliatedAuthor한, 재호-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s00277-017-3115-6-
dc.citation.titleAnnals of hematology-
dc.citation.volume96-
dc.citation.number11-
dc.citation.date2017-
dc.citation.startPage1883-
dc.citation.endPage1890-
dc.identifier.bibliographicCitationAnnals of hematology, 96(11). : 1883-1890, 2017-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1432-0584-
dc.relation.journalidJ009395555-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
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