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Conditional Survival Analysis Demonstrates that Recurrence Risk of Surgically Treated Hepatocellular Carcinoma Evolves with Time

Authors
Park, YK | Song, SK | Kim, BW  | Park, SK | Lee, JI | Lim, SS | Wang, HJ
Citation
Journal of gastrointestinal surgery, 21(8). : 1237-1244, 2017
Journal Title
Journal of gastrointestinal surgery
ISSN
1091-255X1873-4626
Abstract
OBJECTIVE: The study aim was to investigate long-term change in tumor recurrence risk in patients with hepatocellular carcinoma (HCC) after hepatic resection. Recurrence probability over time was estimated by conditional survival (CS) analysis.
PATIENTS AND METHODS: Early-stage HCC patients with hepatic resection were selected for inclusion from our surgery database. Variables predictive of tumor recurrence were identified by univariate and multivariate analyses. Five-year recurrence-free CS probability was calculated for all patients and for risk groups stratified by independent predictors.
RESULTS: In this series of 436 patients, tumor size >5 cm, microvascular invasion, positive resection margin, liver cirrhosis, and a indocyanine green retention ratio at 15 min (ICG-R15) >20% were independently predictive of tumor recurrence. The estimated 5-year recurrence-free CS probability improved with each additional year of recurrence-free survival, and the improvement was significantly greater in the high-risk than in the low- or intermediate-risk groups.
CONCLUSION: CS provides added value during follow-up of early-stage HCC patients treated by surgical resection.
MeSH

DOI
10.1007/s11605-017-3437-7
PMID
28536805
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Ajou Authors
김, 봉완  |  왕, 희정
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