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Effects of combination of change in visceral fat and thigh muscle mass on the development of type 2 diabetes

DC Field Value Language
dc.contributor.authorHan, SJ-
dc.contributor.authorKim, SK-
dc.contributor.authorFujimoto, WY-
dc.contributor.authorKahn, SE-
dc.contributor.authorLeonetti, DL-
dc.contributor.authorBoyko, EJ-
dc.date.accessioned2018-08-24T01:48:41Z-
dc.date.available2018-08-24T01:48:41Z-
dc.date.issued2017-
dc.identifier.issn0168-8227-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/15874-
dc.description.abstractAIM: We investigated the association between combined changes of visceral fat and thigh muscle over 5 years and incident type 2 diabetes in a prospective study of Japanese Americans.
METHODS: We followed 420 nondiabetic Japanese American subjects for 5 years and assessed visceral fat and thigh muscle by computed tomography (CT) at baseline and at 5 years. We categorized study subjects into 4 body composition change groups: visceral fat loss/thigh muscle gain (VF-loss/TM-gain), visceral fat loss/thigh muscle loss (VF-loss/TM-loss), visceral fat gain/thigh muscle gain (VF-gain/TM-gain), and visceral fat gain/thigh muscle loss (VF-gain/TM-loss) by combining changes from baseline in CT measured visceral fat and estimated thigh muscle areas. We fit a logistic regression model to examine the association between body composition categories and the development of incident type 2 diabetes at 5 years.
RESULTS: Cumulative incidence of type 2 diabetes was 9.8% at 5 years. VF-gain/TM-gain and VF-loss/TM-loss groups had higher risk for incident type 2 diabetes in a model adjusted for age, sex, family history of diabetes, and body mass index compared to VF-loss/TM-gain group as the reference category (OR=6.83 (1.85-25.17), 4.55 (1.06-19.48), respectively). However, the VF-gain/TM-loss group did not show a significant association with the odds of incident diabetes (3.24: 95% CI. 0.78-13.47).
CONCLUSIONS: Concordant gain or loss in visceral fat and thigh muscle was related to higher risk of incident type 2 diabetes compared to the reference combination of loss of visceral fat and gain of thigh muscle in Japanese Americans.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBody Composition-
dc.subject.MESHDiabetes Mellitus, Type 2-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHIntra-Abdominal Fat-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMuscle, Skeletal-
dc.subject.MESHProspective Studies-
dc.subject.MESHThigh-
dc.titleEffects of combination of change in visceral fat and thigh muscle mass on the development of type 2 diabetes-
dc.typeArticle-
dc.identifier.pmid29032053-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723555/-
dc.contributor.affiliatedAuthor한, 승진-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.diabres.2017.10.003-
dc.citation.titleDiabetes research and clinical practice-
dc.citation.volume134-
dc.citation.date2017-
dc.citation.startPage131-
dc.citation.endPage138-
dc.identifier.bibliographicCitationDiabetes research and clinical practice, 134. : 131-138, 2017-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1872-8227-
dc.relation.journalidJ001688227-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
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