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Role of N-acetyl galactosamine-4-SO4, a ligand of CD206 in HSV-induced mouse model of Behcet's disease

Authors
Choi, B | Sayeed, HM | Islam, SMS | Sohn, S
Citation
European journal of pharmacology, 813. : 42-49, 2017
Journal Title
European journal of pharmacology
ISSN
0014-29991879-0712
Abstract
CD206 is a macrophage mannose receptor involved in variety of autoimmune and inflammatory diseases. This study aimed to identify the pathogenic role of CD206 in a herpes simplex virus (HSV) induced Behcet's disease (BD) mouse model. CD206 positive cells were detected in peripheral blood mononuclear cells and quantified by flow cytometry. Levels of cytokines were measured by ELISA. CD206 was found to be down-regulated both in vitro (10(-6)M) and in vivo (200mug/mouse) after treatment with N-acetylgalactosamine (GalNAc), a ligand for CD206. The down-regulation of CD206 was correlated with improvement in BD symptoms. Colchicine (2mug/mouse) or pentoxifylline (400mug/mouse) treated mice displayed improvement in BD symptoms with fewer CD206 positive cells. The prevalence of CD206-positive cells differed between ligand-responsive and non-responsive BD mice. Inhibition of CD206 was associated with down-regulated serum level of interleukin-17 in GalNAc-treated BD mice. These results suggest that the expression of CD206 is correlated with HSV-induced BD symptoms in mice, implicating that CD206 might have a pathogenic role in BD.
MeSH

DOI
10.1016/j.ejphar.2017.07.022
PMID
28709621
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
Ajou Authors
손, 성향
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