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Treatment patterns and medication adherence of patients with glaucoma in South Korea

Authors
Kim, CY | Park, KH | Ahn, J  | Ahn, MD | Cha, SC | Kim, HS | Kim, JM | Kim, MJ | Kim, TW | Kim, YY | Lee, JW | Park, SW | Sohn, YH | Sung, KR | Yoo, C | Cha, J | Kim, YJ
Citation
The British journal of ophthalmology, 101(6). : 801-807, 2017
Journal Title
The British journal of ophthalmology
ISSN
0007-11611468-2079
Abstract
BACKGROUND/AIMS: This study aimed to investigate treatment patterns and medication adherence of glaucoma. It also identified key factors associated with non-adherence.
METHODS: It was a cross-sectional, observational study. Patients who use eye-drops for /=80% of prescribed days. Medication adherence rate was calculated by dividing actual number of administration from total prescribed number of administration for 7 days. Patients whose self-reported prescription was different from total daily doses of physicians' prescription were considered as non-adherent.
RESULTS: A total of 1050 patients included, and medication adherence rate was evaluated in 1046 patients whose verification of adherence was available. Of the total, 27.4% were non-adherent, and the medication adherence rates of the total, the adherent, and the non-adherent were 90.6+/-17.8%, 96.8+/-5.5% and 56.6+/-24.7%, respectively. The most commonly used medication was prostaglandin (PGA) alone and the second was combination of two-class (beta-blocker and carbonic anhydrase inhibitor (CAI)) and three-class combination of PGA, beta-blocker and CAI followed. In multivariate analysis, the risk of non-adherence was 1.466 times greater in males than in females (95% CI 1.106 to 1.943) and 1.328-fold greater as the daily number of administration was increased (95% CI 1.186 to 1.487).
CONCLUSION: Approximately, one-third of the patients were non-adherent, and males and increased daily number of administration were associated with non-adherence. It highlights that more systematic treatment strategies should be considered for better medication adherence, leading to effective glaucoma management.
MeSH

DOI
10.1136/bjophthalmol-2016-308505
PMID
28270490
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Ophthalmology
Ajou Authors
안, 재홍
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