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Education Level Is a Strong Prognosticator in the Subgroup Aged More Than 50 Years Regardless of the Molecular Subtype of Breast Cancer: A Study Based on the Nationwide Korean Breast Cancer Registry Database

Authors
Hwang, KT | Noh, W | Cho, SH | Yu, J | Park, MH | Jeong, J | Lee, HJ | Kim, J | Oh, S | Kim, YA | Korean Breast Cancer Society
Citation
Cancer research and treatment, 49(4). : 1114-1126, 2017
Journal Title
Cancer research and treatment
ISSN
1598-29982005-9256
Abstract
PURPOSE: This study investigated the role of the education level (EL) as a prognostic factor for breast cancer and analyzed the relationship between the EL and various confounding factors.
MATERIALS AND METHODS: The data for 64,129 primary breast cancer patients from the Korean Breast Cancer Registry were analyzed. The EL was classified into two groups according to the education period: the high EL group (>/= 12 years) and low EL group (< 12 years). Survival analyses were performed with respect to the overall survival between the two groups.
RESULTS: A high EL conferred a superior prognosis compared to a low EL in the subgroup aged > 50 years (hazard ratio, 0.626: 95% confidence interval [CI], 0.577 to 0.678) but not in the subgroup aged 50 years according to multivariate analyses. The high EL group showed more favorable clinicopathologic features and a higher proportion of patients in this group received lumpectomy, radiation therapy, and endocrine therapy. In the high EL group, a higher proportion of patients received chemotherapy in the subgroups with unfavorable clinicopathologic features. The EL was a significant prognosticator across all molecular subtypes of breast cancer.
CONCLUSION: The EL is a strong independent prognostic factor for breast cancer in the subgroup aged > 50 years regardless of the molecular subtype, but not in the subgroup aged
MeSH

DOI
10.4143/crt.2016.528
PMID
28161933
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
Ajou Authors
한, 세환
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