Cited 0 times in Scipus Cited Count

The impact of microvascular resistance on the discordance between anatomical and functional evaluations of intermediate coronary disease

Seo, KW  | Lim, HS  | Yoon, MH  | Tahk, SJ  | Choi, SY  | Choi, BJ  | Yang, HM  | Shin, JH  | Hwang, GS  | Park, JS  | Jin, X
EuroIntervention, 13(2). : e185-e192, 2017
Journal Title
AIMS: In intermediate coronary artery disease, discordance between anatomical and functional assessments persists and the diagnostic accuracy of an anatomical evaluation is not satisfactory for determining functional significance. We aimed to evaluate the impact of microvascular resistance on "anatomical-functional discordance".
METHODS AND RESULTS: In 97 intermediate coronary lesions of 83 patients, minimum lumen area (MLA), fractional flow reserve (FFR), Delta(Pd/Pa-FFR), and hyperaemic microvascular resistance index (hMVRI) were measured using intravascular ultrasound and an intracoronary dual pressure and Doppler sensor-tipped guidewire. hMVRI correlated with FFR and Delta(Pd/Pa-FFR) (r=0.611, p<0.001: r=-0.509, p<0.001: respectively). After the lesions were categorised into four groups based on functional significance (FFR 0.8) and the MLA cut-off for that (2.5 mm2), hMVRI was higher with a lower Delta(Pd/Pa-FFR) regardless of the MLA group in lesions with FFR >0.8, compared with those in lesions with FFR CONCLUSIONS: Coronary microvascular resistance is associated with anatomical-functional discordance and the ischaemic potential of intermediate epicardial stenosis. In determining a treatment strategy, anatomy alone is insufficient and an integrated physiologic approach is important.

Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
Ajou Authors
박, 진선  |  서, 경우  |  신, 준한  |  양, 형모  |  윤, 명호  |  임, 홍석  |  최, 병주  |  최, 소연  |  탁, 승제  |  황, 교승
Files in This Item:
There are no files associated with this item.


해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.