267 749

Cited 0 times in

Preparation and Characterization of CMC Hydrogels with Porcine Cartilage Acellular Matrix Using Gamma-Irradiation

DC Field Value Language
dc.contributor.authorJeong, SI-
dc.contributor.authorPark, JS-
dc.contributor.authorGwon, HJ-
dc.contributor.authorAn, SJ-
dc.contributor.authorLim, YM-
dc.contributor.authorSong, BR-
dc.contributor.authorKim, YJ-
dc.contributor.authorMin, BH-
dc.contributor.authorKim, MS-
dc.date.accessioned2018-08-29T06:21:30Z-
dc.date.available2018-08-29T06:21:30Z-
dc.date.issued2017-
dc.identifier.issn0379-153X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/16217-
dc.description.abstractIn this study, a novel crosslinked carboxymethyl cellulose sodium salt (CMC) and porcine cartilage acellular matrix (PCAM) hydrogel for adhesion prevention were prepared by gamma-irradiation. CMC is known as a kind of cross-linked natural polymer at highly concentrated aqueous solution under action of gamma-irradiation. The radiationcrosslinked CMC/PCAM hydrogels were characterized by scanning electron microscope (SEM), gel-fraction, gel strength, swelling behavior, and FTIR-ATR spectroscopy. The results showed that the PCAM addition increased the swelling behavior and decreased the gel-fraction and gel strength of CMC/PCAM hydrogels. The degree of attachment and proliferation of human fibroblast on CMC/PCAM hydrogel was lower than the CMC hydrogels. In conclusion, this study suggests that the radiation cross-linked CMC/PCAM hydrogels may be useful as an anti-adhesion barrier.-
dc.description.abstract본 연구는 감마선을 이용하여 가교된 유착방지용 carboxymethyl cellulose sodium salt(CMC-Na)와 porcine cartilage acellular matrix(PCAM) 수화젤을 제조하였다. CMC는 높은 농도의 수용액에서 감마선에 의해 가교가 되는 천연고분자 중에 하나이다. 방사선 가교된 CMC/PCAM 수화젤의 물리/화학적 특성을 알기 위해 SEM, 젤화율, 젤강도, 팽윤도, FTIR-ATR 등 분석을 통해 특성을 확인하였다. 감마선으로 가교된 CMC/PCAM 수화젤에서 PCAM 비율이 증가할수록 젤화율과 젤강도는 감소하였고 팽윤도는 증가하였다. 또한 CMC/PCAM 수화젤에서 세포의 부착도와 증식도가 CMC 수화젤에 비해 낮음을 확인하였다. 결론적으로, 본 연구에서는 방사선으로 가교된 CMC/PCAM 수화젤은 유착방지를 위한 유착방지제로서 응용이 기대된다.-
dc.language.isoko-
dc.titlePreparation and Characterization of CMC Hydrogels with Porcine Cartilage Acellular Matrix Using Gamma-Irradiation-
dc.title.alternative감마선을 이용한 돼지 무세포 연골세포외기질이 함유된 CMC 수화젤의 제조 및 특성 연구-
dc.typeArticle-
dc.subject.keywordCarboxymethyl cellulose sodium salt-
dc.subject.keywordPorcine cartilage acellular matrix-
dc.subject.keywordHydrogel-
dc.subject.keywordGamma-irradiation-
dc.subject.keywordCrosslinking-
dc.subject.keywordAdhesion prevention-
dc.contributor.affiliatedAuthor김, 영직-
dc.contributor.affiliatedAuthor민, 병현-
dc.type.localJournal Papers-
dc.identifier.doi10.7317/pk.2017.41.1.151-
dc.citation.titlePOLYMER(KOREA)-
dc.citation.volume41-
dc.citation.number1-
dc.citation.date2017-
dc.citation.startPage151-
dc.citation.endPage156-
dc.identifier.bibliographicCitationPOLYMER(KOREA), 41(1). : 151-156, 2017-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn2234-8077-
dc.relation.journalidJ00379153X-
Appears in Collections:
Journal Papers > Research Organization > Cell Therapy Center
Journal Papers > School of Medicine / Graduate School of Medicine > Orthopedic Surgery
Files in This Item:
10.7317_pk.2017.41.1.151.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse