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Association of the miR-196a2, miR-146a, and miR-499 Polymorphisms with Asthma Phenotypes in a Korean Population

Trinh, HKT; Pham, DL; Kim, SC; Kim, RY; Park, HS; Kim, SH
Molecular diagnosis & therapy, 21(5):547-554, 2017
Journal Title
Molecular diagnosis & therapy
BACKGROUND: MicroRNAs (miRNAs) modulate expressions of inflammatory genes, thereby regulating inflammatory responses. Single nucleotide polymorphisms (SNPs) in miRNAs could affect their efficiency in binding to messenger RNAs (mRNAs).
OBJECTIVE: We investigated the associations of miRNA SNPs with asthma phenotypes. miR-196a2 (rs11614913 T>C), miR-146a (rs2910164 C>G), and miR-499 (rs3746444 A>G) were genotyped in 347 asthma patients and 172 normal healthy controls (NCs).
RESULTS: The CT/CC genotype of miR-196a2 rs11614913 was associated with eosinophilic asthma (p = 0.004) and a higher sputum eosinophil count compared with the TT genotype (p = 0.003). The CG/GG genotype of miR-146a rs2910164 tended to be associated with higher bronchial hyperresponsiveness to methacholine (PC20) compared with the CC genotype. The AG/GG genotype of miR-499 rs3746444 was associated with higher predicted values of forced expiratory volume in 1 s (%FEV1) compared with the AA genotype (p = 0.008).
CONCLUSIONS: Genetic polymorphisms in miR-196a2, miR-146a, and miR-499 could be potential biomarkers for asthma phenotypes and targets for asthma treatments in a Korean population.
MeSH terms
AdultAsian Continental Ancestry Group/genetics*Asthma/genetics*Asthma/pathologyAsthma/physiopathologyCase-Control StudiesEosinophils/pathologyFemaleForced Expiratory VolumeGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansMaleMicroRNAs/genetics*Middle AgedPolymorphism, Single Nucleotide*Sputum/cytologySputum/immunologyYoung Adult
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Research Organization > Regional Clinical Trial Center
AJOU Authors
박, 해심김, 승현
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