Cited 0 times in Scipus Cited Count

Dipeptidyl Peptidase-4 Inhibitors and Risk of Heart Failure in Patients With Type 2 Diabetes Mellitus: A Population-Based Cohort Study

DC Field Value Language
dc.contributor.authorKim, YG-
dc.contributor.authorYoon, D-
dc.contributor.authorPark, S-
dc.contributor.authorHan, SJ-
dc.contributor.authorKim, DJ-
dc.contributor.authorLee, KW-
dc.contributor.authorPark, RW-
dc.contributor.authorKim, HJ-
dc.date.accessioned2018-08-31T04:48:20Z-
dc.date.available2018-08-31T04:48:20Z-
dc.date.issued2017-
dc.identifier.issn1941-3289-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/16243-
dc.description.abstractBACKGROUND: The association between dipeptidyl-peptidase IV inhibitors (DPP-4i) and heart failure (HF) remains unclear. In 1 randomized controlled trial and some observational studies, DPP-4i reportedly increased the risk of HF, but 2 other randomized controlled trials and observational studies have shown no such risk. Here, we evaluated the risk of HF and cardiovascular outcomes of DPP-4i compared with sulfonylureas.
METHODS AND RESULTS: A population-based retrospective cohort study was conducted using the Korean Health Insurance Review and Assessment Service database from January 1, 2009, to December 31, 2015. Incident users of sulfonylurea and DPP-4i who were not prescribed the comparator drug in the year before treatment initiation were included. DPP-4i-treated and sulfonylurea-treated patients were matched on propensity score, calculated with >40 variables. The risk of hospitalization for HF was evaluated with a Cox proportional hazards model in 255 691 matched pairs. Analyses were conducted in the total patient population and in both strata divided by the presence of cardiovascular disease during the baseline period. The hazard ratios (HRs) of hospitalization for HF for DPP-4i-treated patients were 0.78 (95% confidence interval [CI], 0.67-0.86) in all of the patients, 0.77 (95% CI, 0.68-0.79) in patients with baseline cardiovascular disease, and 0.71 (95% CI, 0.56-0.90) in patients without baseline cardiovascular disease compared with HRs for sulfonylurea-treated patients. Sitagliptin and linagliptin showed statistically lower risk for hospitalization for HF (HR, 0.76: 95% CI, 0.67-0.86 for sitagliptin-prescribed patients: HR, 0.74: 95% CI, 0.59-0.92 for linagliptin-prescribed patients) than for sulfonylurea. The HRs for hospitalization for myocardial infarction and stroke with the use of a DPP-4i versus sulfonylurea were HR, 0.76 (95% CI, 0.67-0.87) and HR, 0.63 (95% CI, 0.60-0.67), respectively.
CONCLUSIONS: Our findings suggest that DPP-4i use did not increase the risk of HF compared with sulfonylurea. In addition, the risks for cardiovascular outcomes were not elevated in DPP-4i-treated patients compared with sulfonylurea-treated patients.
-
dc.language.isoen-
dc.subject.MESHAdministrative Claims, Healthcare-
dc.subject.MESHAged-
dc.subject.MESHDatabases, Factual-
dc.subject.MESHDiabetes Mellitus, Type 2-
dc.subject.MESHDipeptidyl Peptidase 4-
dc.subject.MESHDipeptidyl-Peptidase IV Inhibitors-
dc.subject.MESHFemale-
dc.subject.MESHHeart Failure-
dc.subject.MESHHospitalization-
dc.subject.MESHHumans-
dc.subject.MESHHypoglycemic Agents-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPropensity Score-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Assessment-
dc.subject.MESHRisk Factors-
dc.subject.MESHSulfonylurea Compounds-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.titleDipeptidyl Peptidase-4 Inhibitors and Risk of Heart Failure in Patients With Type 2 Diabetes Mellitus: A Population-Based Cohort Study-
dc.typeArticle-
dc.identifier.pmid28899989-
dc.contributor.affiliatedAuthor윤, 덕용-
dc.contributor.affiliatedAuthor한, 승진-
dc.contributor.affiliatedAuthor김, 대중-
dc.contributor.affiliatedAuthor이, 관우-
dc.contributor.affiliatedAuthor박, 래웅-
dc.contributor.affiliatedAuthor김, 혜진-
dc.type.localJournal Papers-
dc.identifier.doi10.1161/CIRCHEARTFAILURE.117.003957-
dc.citation.titleCirculation. Heart failure-
dc.citation.volume10-
dc.citation.number9-
dc.citation.date2017-
dc.citation.startPagee003957-
dc.citation.endPagee003957-
dc.identifier.bibliographicCitationCirculation. Heart failure, 10(9). : e003957-e003957, 2017-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1941-3297-
dc.relation.journalidJ019413289-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Biomedical Informatics
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse