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A Novel Wound Management Strategy with Silver-coated Vacuum Dressing on Infected Wound: In Vitro Study

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dc.contributor.authorLee, IJ-
dc.contributor.authorChoi, JH-
dc.contributor.authorHong, MK-
dc.contributor.authorHahn, HM-
dc.contributor.authorPark, BY-
dc.date.accessioned2018-09-27T08:00:44Z-
dc.date.available2018-09-27T08:00:44Z-
dc.date.issued2017-
dc.identifier.issn2586-0402-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/16357-
dc.description.abstractBackground: Nowadays, although Negative Pressure Wound Therapy’s (NPWT) efficacy on healing wounds is widely known, it still has limited applications on infected wounds. Meanwhile, silver-containing foam dressings have been used for infected wounds ever since silver established a notable place in the material industry for its antibacterial properties. In this study, we design an experiment to investigate quantitatively the efficacy of silver-coated dressing materials and its antibacterial effects.
Methods: We prepared a NPWT device with silver-coated foam (Curavac®) and freeze-dried standard laboratory strains that are common wound pathogens: S. aureus (ATCC 25923), methicillin-resistant S. aureus (KCTC 3881), E. coli (KCTC 2571) and P. aeruginosa (KCTC 2513) bacteria and bouillon culture-medium, which were provided by the Hospital Microbiology laboratory. All reagents were used as-is without further purifications. Each pathogen was divided into five groups: 1) control, 2) pathogen with conventional pore foam (without pressure), 3) pathogen with silver-coated foam (without pressure), 4) pathogen with conventional pore foam (with pressure), and 5) pathogen with silver-coated foam (with pressure). The number of bacterial colonies in each agar plate was evaluated after 72 hours by applying dressings and measuring inhibition zones.
Results: The number of bacterial colonies of the a silver-coated foam group was significantly lower than the control group except one pathogen (E. coli) without pressure, and the bacterial colonies of silver-coated foam were significantly lower in all pathogen groups with pressure.
Conclusion: This study demonstrated that the antibacterial effects of silver-coated dressing materials using quantitative analysis. Severely injured patients often develop wound infections, for which there is no obvious therapeutic approach yet. This study can suggest a novel wound management tool for such patients while also expecting to achieve faster surgical intervention with definite antibacterial effects.
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dc.language.isoko-
dc.titleA Novel Wound Management Strategy with Silver-coated Vacuum Dressing on Infected Wound: In Vitro Study-
dc.typeArticle-
dc.subject.keywordNegative pressure wound therapy-
dc.subject.keywordSilver-
dc.subject.keywordWound infection-
dc.contributor.affiliatedAuthor이, 일재-
dc.contributor.affiliatedAuthor한, 형민-
dc.type.localJournal Papers-
dc.identifier.doi10.22467/jwmr.2017.00129-
dc.citation.titleJournal of Wound Management and Research-
dc.citation.volume13-
dc.citation.number2-
dc.citation.date2017-
dc.citation.startPage49-
dc.citation.endPage52-
dc.identifier.bibliographicCitationJournal of Wound Management and Research, 13(2). : 49-52, 2017-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn2586-0410-
dc.relation.journalidJ025860402-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Plastic & Reconstructive Surgery
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