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Pharmacokinetics and effect on the corrected QT interval of single-dose escitalopram in healthy elderly compared with younger adults

Authors
Chung, H; Kim, A; Lim, KS; Park, SI; Yu, KS; Yoon, SH; Cho, JY; Chung, JY
Citation
International clinical psychopharmacology, 32(1):20-26, 2017
Journal Title
International clinical psychopharmacology
ISSN
0268-13151473-5857
Abstract
Escitalopram is the (S)-enantiomer of citalopram that has a potential QT prolonging effect. In this study, 12 healthy elderly individuals received a single oral dose of escitalopram (20 mg), and their pharmacokinetics and QT effect data were compared with data from 33 younger adults obtained in a previous study. Serial blood samples for pharmacokinetic analysis were collected and ECG was performed up to 48 h postdose. The elderly and younger adults showed similar pharmacokinetic profiles. The geometric mean ratios (90% confidence interval) of the elderly compared with the younger adults were 1.02 (0.89-1.17) and 1.01 (0.86-1.17) for the maximum plasma concentration and area under the concentration-time curve, respectively. The mean baseline-adjusted QT (dQT) time profiles were similar and the mean values of maximum dQT were not significantly different between the elderly and the younger adults. The linear mixed-effect model indicated a weak but positive relationship between the escitalopram concentration and dQT, with an estimated coefficient of concentration of 0.43-0.54. In conclusion, the pharmacokinetics and QT effect of a single dose of escitalopram observed in the elderly without comorbidities and younger adults were generally similar.
MeSH terms
Administration, OralAdultAgedAged, 80 and overCitalopram/administration & dosage*Citalopram/pharmacokinetics*Electrocardiography/drug effects*FemaleHeart Rate/drug effects*Heart Rate/physiologyHumansMaleProspective StudiesRepublic of Korea/epidemiologySerotonin Uptake Inhibitors/administration & dosage*Serotonin Uptake Inhibitors/pharmacokinetics*Young Adult
DOI
10.1097/YIC.0000000000000149
PMID
27741028
Appears in Collections:
Journal Papers > Research Organization > Regional Clinical Trial Center
AJOU Authors
김, 언혜
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