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Plasma MicroRNA-21, 26a, and 29a-3p as Predictive Markers for Treatment Response Following Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma

Kim, SS  | Cho, HJ  | Nam, JS | Kim, HJ  | Kang, DR | Won, JH  | Kim, J  | Kim, JK  | Lee, JH  | Kim, BH  | Lee, MY | Cho, SW  | Cheong, JY
Journal of Korean medical science, 33(1). : e6-e6, 2018
Journal Title
Journal of Korean medical science
BACKGROUND: We investigated an association between the levels of plasma microRNA (miRNA)-21, -26a, and -29a-3p and treatment outcomes following transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC).
METHODS: A total of 198 patients with TACE-treated HCC were followed up for TACE refractoriness and liver transplantation (LT)-free survival. Pretreatment plasma miRNA-21, -26a, and -29a-3p levels were measured using quantitative real-time polymerase chain reaction.
RESULTS: During the mean follow-up of 22.3 (range, 0.7-79) months, 118 (59.6%) patients exhibited TACE refractoriness. Multivariate analyses showed that expression of a specific combination of miRNAs (miRNA-21 >/= 2.5, miRNA-26a >/= 1.5, and miRNA-29a-3p < 0.4) was associated with early TACE refractoriness (within 1 year: hazard ratio [HR], 2.32: 95% confidence interval [CI], 1.08-4.99: P = 0.031) together with tumor size (HR, 4.62: 95% CI, 1.50-14.21: P = 0.008), and macrovascular invasion (HR, 3.80: 95% CI, 1.19-12.20: P = 0.025). However, miRNA-21, -26a, and -29a-3p levels were not significantly associated with overall TACE refractoriness or LT-free survival. Additionally, large tumor size and macrovascular invasion were common predictive factor of overall TACE refractoriness and survival.
CONCLUSION: Combination of plasma miRNA-21, -26a, and -29a-3p expression could predict early TACE refractoriness in patients with TACE-treated HCC.


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Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
Ajou Authors
김, 보현  |  김, 순선  |  김, 재근  |  김, 진우  |  김, 현지  |  원, 제환  |  이, 제희  |  정, 재연  |  조, 성원  |  조, 효정
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