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Identification of the Thioredoxin-Like 2 Autoantibody as a Specific Biomarker for Triple-Negative Breast Cancer

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dc.contributor.authorChung, JM-
dc.contributor.authorJung, Y-
dc.contributor.authorKim, YP-
dc.contributor.authorSong, J-
dc.contributor.authorKim, S-
dc.contributor.authorKim, JY-
dc.contributor.authorKwon, M-
dc.contributor.authorYoon, JH-
dc.contributor.authorKim, MD-
dc.contributor.authorLee, JK-
dc.contributor.authorChung, DY-
dc.contributor.authorLee, SY-
dc.contributor.authorKang, J-
dc.contributor.authorKang, HC-
dc.date.accessioned2019-11-13T00:17:50Z-
dc.date.available2019-11-13T00:17:50Z-
dc.date.issued2018-
dc.identifier.issn1738-6756-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/16771-
dc.description.abstractTriple-negative breast cancer (TNBC) has a higher risk of death within 5 years of being diagnosed than the other forms of breast cancer. It is the second leading cause of death due to cancer among women. Currently, however, no diagnostic blood-based biomarker exists to identify the early stages of TNBC. To address this point, we utilized a human protein microarray system to identify serum autoantibodies that showed different expression patterns between TNBC and normal serum samples, and identified five autoantibodies showing TNBC-specific expression. Among them, we selected the thioredoxin-like 2 (TXNL2) autoantibody and evaluated its diagnostic relevance by dot blot analysis with the recombinant TXNL2 protein. We demonstrated that the TXNL2 autoantibody showed 2- to 6-fold higher expression in TNBC samples than in normal samples suggesting that serum TXNL2 autoantibodies are potential biomarkers for TNBC.-
dc.language.isoen-
dc.titleIdentification of the Thioredoxin-Like 2 Autoantibody as a Specific Biomarker for Triple-Negative Breast Cancer-
dc.typeArticle-
dc.identifier.pmid29628988-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880970/-
dc.subject.keywordAutoantibodies-
dc.subject.keywordBiomarkers-
dc.subject.keywordBreast neoplasms-
dc.subject.keywordProtein array analysis-
dc.contributor.affiliatedAuthor정, 용식-
dc.contributor.affiliatedAuthor김, 지영-
dc.contributor.affiliatedAuthor이, 서윤-
dc.contributor.affiliatedAuthor강, 호철-
dc.type.localJournal Papers-
dc.identifier.doi10.4048/jbc.2018.21.1.87-
dc.citation.titleJournal of breast cancer-
dc.citation.volume21-
dc.citation.number1-
dc.citation.date2018-
dc.citation.startPage87-
dc.citation.endPage90-
dc.identifier.bibliographicCitationJournal of breast cancer, 21(1). : 87-90, 2018-
dc.identifier.eissn2092-9900-
dc.relation.journalidJ017386756-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
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