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Astrocytes, Microglia, and Parkinson's Disease

Authors
Joe, EH  | Choi, DJ  | An, J | Eun, JH | Jou, I  | Park, S
Citation
Experimental neurobiology, 27(2). : 77-87, 2018
Journal Title
Experimental neurobiology
ISSN
1226-25602093-8144
Abstract
Astrocytes and microglia support well-being and well-function of the brain through diverse functions in both intact and injured brain. For example, astrocytes maintain homeostasis of microenvironment of the brain through up-taking ions and neurotransmitters, and provide growth factors and metabolites for neurons, etc. Microglia keep surveying surroundings, and remove abnormal synapses or respond to injury by isolating injury sites and expressing inflammatory cytokines. Therefore, their loss and/or functional alteration may be directly linked to brain diseases. Since Parkinson's disease (PD)-related genes are expressed in astrocytes and microglia, mutations of these genes may alter the functions of these cells, thereby contributing to disease onset and progression. Here, we review the roles of astrocytes and microglia in intact and injured brain, and discuss how PD genes regulate their functions.
Keywords
DOI
10.5607/en.2018.27.2.77
PMID
29731673
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
Journal Papers > Research Organization > Inflamm-aging Translational Research Center
Ajou Authors
박, 상면  |  조, 은혜  |  주, 일로  |  최, 동주
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