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Comparative Cardiovascular Risks of Dipeptidyl Peptidase-4 Inhibitors: Analyses of Real-world Data in Korea

Authors
Ha, KH  | Kim, B | Shin, HS | Lee, J | Choi, H | Kim, HC | Kim, DJ
Citation
Korean circulation journal, 48(5). : 395-405, 2018
Journal Title
Korean circulation journal
ISSN
1738-55201738-5555
Abstract
BACKGROUND AND OBJECTIVES: To compare cardiovascular disease (CVD) risk associated with 5 different dipeptidyl peptidase-4 inhibitors (DPP-4is) in people with type 2 diabetes.
METHODS: We identified 534,327 people who were newly prescribed sitagliptin (n=167,157), vildagliptin (n=67,412), saxagliptin (n=29,479), linagliptin (n=220,672), or gemigliptin (n=49,607) between January 2013 and June 2015 using the claims database of the Korean National Health Insurance System. A Cox proportional hazards model was used to estimate hazard ratios (HRs) for major CVD events (myocardial infarction, stroke, or death) among users of different DPP-4is. The model was adjusted for sex, age, duration of DPP-4i use, use of other glucose-lowering drugs, use of antiplatelet agents, hypertension, dyslipidemia, atrial fibrillation, chronic kidney disease, microvascular complications of diabetes, Charlson comorbidity index, and the calendar index year as potential confounders.
RESULTS: Compared to sitagliptin users, the fully adjusted HRs for CVD events were 0.97 (95% confidence interval [CI], 0.94-1.01: p=0.163) for vildagliptin, 0.76 (95% CI, 0.71-0.81: p<0.001) for saxagliptin, 0.95 (95% CI, 0.92-0.98: p<0.001) for linagliptin, and 0.84 (95% CI, 0.80-0.88: p<0.001) for gemigliptin.
CONCLUSIONS: Compared to sitagliptin therapy, saxagliptin, linagliptin, and gemigliptin therapies were all associated with a lower risk of cardiovascular events.
Keywords
DOI
10.4070/kcj.2017.0324
PMID
29671284
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Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
Ajou Authors
김, 대중  |  하, 경화
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