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Impact of body fat distribution on long-term clinical outcomes after drug-eluting stent implantation

Authors
Park, SJ | Lim, HS  | Sheen, SS  | Yang, HM  | Seo, KW  | Choi, SY  | Choi, BJ  | Yoon, MH  | Tahk, SJ
Citation
PloS one, 13(5). : e0197991-e0197991, 2018
Journal Title
PloS one
ISSN
1932-6203
Abstract
BACKGROUND AND OBJECTIVE: The distribution of body fat is closely related to cardiovascular disease and outcomes, although its impact on patient prognosis after percutaneous coronary intervention (PCI) with drug-eluting stent (DES) has not been evaluated. We investigated the impact of truncal fat distribution on long-term clinical outcomes after DES treatment.
METHODS: In 441 DES-treated patients, dual energy X-ray absorptiometry was performed to assess total and regional body fat distribution after index PCI. The ratio of truncal fat to total body fat mass (%FMtrunk/FMtotal) was calculated as a representative parameter for truncal fat distribution. The primary endpoint was major adverse cardiac events (MACE), a composite of ischemia-driven target vessel revascularization (TVR), non-procedural myocardial infarction, cardiac death at 5 years.
RESULTS: During the median follow-up duration of 1780 days, MACE occurred in 22.0% of patients, with the highest-quartile group of %FMtrunk/FMtotal having a higher rate than the lowest quartile group (27.8% vs. 15.3%: log rank p = 0.026). The difference was driven by a higher rate of ischemia-driven TVR (25.9% vs. 9.9%: log rank p = 0.008). In multivariable Cox regression analyses, %FMtrunk/FMtotal was independently associated with MACE (hazard ratio: 1.075: 95% CI: 1.022-1.131: p = 0.005), but body mass index (BMI) was not.
CONCLUSIONS: In DES-treated patients, truncal fat distribution is associated with unfavorable clinical outcomes and is more clinically relevant than BMI.
MeSH

DOI
10.1371/journal.pone.0197991
PMID
29799868
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
Ajou Authors
서, 경우  |  신, 승수  |  양, 형모  |  윤, 명호  |  임, 홍석  |  최, 병주  |  최, 소연  |  탁, 승제
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