171 428

Cited 0 times in

Assessment of Quality of Life and Safety in Postmenopausal Breast Cancer Patients Receiving Letrozole as an Early Adjuvant Treatment

Authors
Jung, Y  | Lee, SJ | Lee, J | Noh, WC | Nam, SJ | Park, BW | Bae, YT | Kang, SS | Park, HK | Yoon, JH | Kim, JR | Cho, SH | Kim, LS | Moon, BI | Jung, SH | Lim, CW | Kim, SY | Park, HY | Song, J | Lee, KM | Park, SH | Jeong, J | Park, HL | Kim, SW | Kwak, BS | Kang, SH | Cho, YU | Gwak, GH | Park, YL | Kim, SW | Han, S
Citation
Journal of breast cancer, 21(2). : 182-189, 2018
Journal Title
Journal of breast cancer
ISSN
1738-67562092-9900
Abstract
PURPOSE: There are few reports from Asian countries about the long-term results of aromatase inhibitor adjuvant treatment for breast cancer. This observational study aimed to evaluate the long-term effects of letrozole in postmenopausal Korean women with operable breast cancer.
METHODS: Self-reported quality of life (QoL) scores were serially assessed for 3 years during adjuvant letrozole treatment using the Korean version of the Functional Assessment of Cancer Therapy-Breast questionnaires (version 3). Changes in bone mineral density (BMD) and serum cholesterol levels were also examined.
RESULTS: All 897 patients received the documented informed consent form and completed a baseline questionnaire before treatment. Adjuvant chemotherapy was administered to 684 (76.3%) subjects, and 410 (45.7%) and 396 (44.1%) patients had stage I and II breast cancer, respectively. Each patient completed questionnaires at 3, 6, 12, 18, 24, 30, and 36 months after enrollment. Of 897 patients, 749 (83.5%) completed the study. The dropout rate was 16.5%. The serial trial outcome index, the sum of the physical and functional well-being subscales, increased gradually and significantly from baseline during letrozole treatment (p<0.001). The mean serum cholesterol level increased significantly from 199 to 205 after 36 months (p=0.042). The mean BMD significantly decreased from -0.39 at baseline to -0.87 after 36 months (p<0.001).
CONCLUSION: QoL gradually improved during letrozole treatment. BMD and serum cholesterol level changes were similar to those in Western countries, indicating that adjuvant letrozole treatment is well tolerated in Korean women, with minimal ethnic variation.
Keywords
DOI
10.4048/jbc.2018.21.2.182
PMID
29963114
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
Ajou Authors
정, 용식  |  한, 세환
Full Text Link
Files in This Item:
29963114.pdfDownload
Export

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse