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Impact of varying levels of hyperglycemia on clinicoradiographic outcomes after endovascular reperfusion treatment

Authors
Lee, SJ  | Hwang, YH | Hong, JM  | Choi, JW  | Yoon, BS | Kang, DH | Kim, YW | Kim, YS | Hong, JH | Yoo, J | Kim, CH | Ovbiagele, B | Demchuk, AM | Sohn, SI | Lee, JS
Citation
Scientific reports, 8(1). : 9832-9832, 2018
Journal Title
Scientific reports
ISSN
2045-2322
Abstract
We evaluated the effects of admission hyperglycemia with different cut-off levels on 3-month outcomes, infarct growth, and hemorrhagic transformation in acute stroke patients with large artery occlusion of anterior circulation who received endovascular treatment (EVT). Between January 2011 and May 2016, patients that underwent EVT with pre-procedural and post-procedural diffusion-weighted imaging were identified from a multicenter registry. Normoglycemia was defined as a glucose level 110 and 170 mg/dL. Its effects on poor outcomes (3-month modified Rankin Scale score 3-6), infarct growth, and parenchymal hematoma type 2 were analyzed. Of 720 patients encountered, 341 patients were eligible. There was a statistically significant difference in glycated hemoglobin levels between the normoglycemia/moderate hyperglycemia and overt hyperglycemia groups (p < 0.001). Moderate hyperglycemia (odds ratio 2.37 [95% confidence interval 1.26-4.45], p = 0.007) and overt hyperglycemia (2.84 [1.19-6.81], p = 0.019) were associated with poor outcomes. Post-procedural infarct volumes were significantly greater in hyperglycemic patients (padjusted = 0.003). Only overt hyperglycemia (9.28 [1.66-51.88], p = 0.011) was associated with parenchymal hematoma type 2. Overall hyperglycemia was associated with poor outcomes and infarct growth, whereas overt hyperglycemia was associated with parenchymal hematoma type 2.
DOI
10.1038/s41598-018-28175-6
PMID
29959399
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
Ajou Authors
이, 성준  |  이, 진수  |  최, 진욱  |  홍, 지만
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