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Characteristic patterns of HLA presentation and T cell differentiation in adult-onset Still's disease

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dc.contributor.authorJung, JY-
dc.contributor.authorChoi, B-
dc.contributor.authorSayeed, HM-
dc.contributor.authorSuh, CH-
dc.contributor.authorKim, YW-
dc.contributor.authorKim, HA-
dc.contributor.authorSohn, S-
dc.date.accessioned2019-11-13T00:19:02Z-
dc.date.available2019-11-13T00:19:02Z-
dc.date.issued2018-
dc.identifier.issn0394-6320-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/17066-
dc.description.abstractWe examined the expression of human leukocyte antigen (HLA) and composition of differentiated T cells in the peripheral blood to understand the characteristics of the immune changes in patients with adult-onset Still's disease (AOSD). This study enrolled patients with AOSD (n = 14), patients with rheumatoid arthritis (RA, n = 20), and healthy controls (HC, n = 20). The percentage of surface-stained cells with HLA-DP, DQ, and DR alleles and the composition of differentiated T cells in peripheral blood leukocytes (PBLs) were evaluated by flow cytometry. AOSD patients exhibited significantly higher percentages of lymphocytes presenting HLA-DP and HLA-DR, and lower percentages of cells presenting HLA-DQ, than RA patients or HC. The proportions of CD4+, CD4+CCR7+, CD4+CD62L-, and CD8+CD62L- cells from PBLs were decreased in AOSD patients relative to RA patients or HCs. By contrast, AOSD patients had higher proportions of CD8+naive T cells in whole blood relative to RA patients or HC. The proportions of CD4+ effector memory T cells, CD8+ naive T cells, and CD8+ effector memory T cells in whole blood cells and CD4+ effector memory T cell in lymphocytes were significantly associated with the systemic score. While the proportions of CD4+, CD8+, CCR7+, CD4+CCR7+, CD4+CD62L-, and CD8+CD62L- cells were significantly decreased in AOSD patients, and the proportion of CD8+naive T cells was elevated in AOSD and correlated with the systemic score. Further studies of a large cohort of AOSD patients will be necessary to evaluate these markers in the pathogenesis of AOSD.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCell Differentiation-
dc.subject.MESHFemale-
dc.subject.MESHHLA Antigens-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHStill's Disease, Adult-Onset-
dc.subject.MESHT-Lymphocytes-
dc.titleCharacteristic patterns of HLA presentation and T cell differentiation in adult-onset Still's disease-
dc.typeArticle-
dc.identifier.pmid30052100-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073833/-
dc.subject.keywordadult-onset still’s disease-
dc.subject.keywordbiomarker-
dc.subject.keyworddisease activity-
dc.subject.keywordhuman leukocyte antigen-
dc.subject.keywordT cell-
dc.contributor.affiliatedAuthor정, 주양-
dc.contributor.affiliatedAuthor서, 창희-
dc.contributor.affiliatedAuthor김, 현아-
dc.contributor.affiliatedAuthor손, 성향-
dc.type.localJournal Papers-
dc.identifier.doi10.1177/2058738418791284-
dc.citation.titleInternational journal of immunopathology and pharmacology-
dc.citation.volume32-
dc.citation.date2018-
dc.citation.startPage2058738418791284-
dc.citation.endPage2058738418791284-
dc.identifier.bibliographicCitationInternational journal of immunopathology and pharmacology, 32. : 2058738418791284-2058738418791284, 2018-
dc.identifier.eissn2058-7384-
dc.relation.journalidJ003946320-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
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