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Serum markers and development of delayed neuropsychological sequelae after acute carbon monoxide poisoning: anion gap, lactate, osmolarity, S100B protein, and interleukin-6

Authors
Kim, H | Choi, S  | Park, E  | Yoon, E | Min, Y  | Lampotang, S
Citation
Clinical and experimental emergency medicine, 5(3). : 185-191, 2018
Journal Title
Clinical and experimental emergency medicine
ISSN
2383-4625
Abstract
OBJECTIVE: Reliable biomarkers of delayed neuropsychological sequelae (DNS) after acute carbon monoxide (CO) poisoning are lacking. This study investigated the associations between potential serum markers and the development of DNS after acute CO poisoning.
METHODS: Retrospective chart reviews were conducted for patients diagnosed with acute CO poisoning during a 28-month period. The patients were divided into two groups according to the presence or absence of having developed DNS. Multivariate analysis was performed to identify predictors of DNS after CO poisoning.
RESULTS: Of a total of 102 patients, 10 (9.8%) developed DNS. The levels of serum osmolarity, S100B protein, and serum lactate, as well as serum anion gap, were statistically significant in univariate analysis. Multiple logistic regression analysis showed that anion gap (adjusted odds ratio [AOR], 1.36: 95% confidence interval [CI], 1.11 to 1.88), serum lactate level (AOR, 1.74: 95% CI, 1.26 to 2.75), and serum S100B protein level ([AOR, 7.02x105: 95% CI, 4.56x102 to 9.00x1010] in model 1, [AOR, 3.69x105: 95% CI, 2.49x102 to 2.71x1011] in model 2) were independently associated with DNS development.
CONCLUSION: Based on our preliminary results, serum lactate level, serum anion gap, and serum S100B protein level in the emergency department could be informative predictors of DNS development in patients with acute CO poisoning. These markers might have the potential to improve early recognition of DNS in patients with acute CO poisoning.
Keywords

DOI
10.15441/ceem.17.217
PMID
30269454
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Emergency Medicine
Ajou Authors
민, 영기  |  박, 은정  |  최, 상천
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