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Association between Serum Uric Acid and Oxidative Stress in Korean Adults

Authors
Ok, EJ | Kim, K | Park, SB
Citation
Korean journal of family medicine, 39(5). : 295-299, 2018
Journal Title
Korean journal of family medicine
ISSN
2005-64432092-6715
Abstract
BACKGROUND: Oxidative stress is implicated in the pathogenesis and development of lifestyle-related diseases. In the present study, we evaluated the correlation between the serum uric acid (UA) levels and oxidative status in Korean adults.
METHODS: The subjects were 5,093 individuals (2,041 women and 3,052 men) who underwent a health checkup between June 2012 and December 2016. Oxidative stress levels (derivatives of reactive oxygen metabolites [d-ROMs]) and antioxidant potential (biological antioxidant potential [BAP]) were measured. Metabolic markers, including UA, were also examined.
RESULTS: Higher serum UA levels were associated with decreased levels of d-ROMs (P<0.05). The UA levels were positively associated with BAP levels (P<0.001).
CONCLUSION: Serum UA is related to oxidative status, especially antioxidant capacity, in Korean adults: UA may play a role in antioxidant defense systems in humans.
Keywords

DOI
10.4082/kjfm.17.0034
PMID
30196649
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Family Practice & Community Health
Ajou Authors
박, 샛별
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