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Low-Tube-Voltage CT Urography Using Low-Concentration-Iodine Contrast Media and Iterative Reconstruction: A Multi-Institutional Randomized Controlled Trial for Comparison with Conventional CT Urography

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dc.contributor.authorKim, SY-
dc.contributor.authorCho, JY-
dc.contributor.authorLee, J-
dc.contributor.authorHwang, SI-
dc.contributor.authorMoon, MH-
dc.contributor.authorLee, EJ-
dc.contributor.authorHong, SS-
dc.contributor.authorKim, CK-
dc.contributor.authorKim, KA-
dc.contributor.authorPark, SB-
dc.contributor.authorSung, DJ-
dc.contributor.authorKim, Y-
dc.contributor.authorKim, YM-
dc.contributor.authorJung, SI-
dc.contributor.authorRha, SE-
dc.contributor.authorKim, DW-
dc.contributor.authorLee, H-
dc.contributor.authorShim, Y-
dc.contributor.authorHwang, I-
dc.contributor.authorWoo, S-
dc.contributor.authorChoi, HJ-
dc.date.accessioned2019-11-13T00:20:46Z-
dc.date.available2019-11-13T00:20:46Z-
dc.date.issued2018-
dc.identifier.issn1229-6929-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/17280-
dc.description.abstractOBJECTIVE: To compare the image quality of low-tube-voltage and low-iodine-concentration-contrast-medium (LVLC) computed tomography urography (CTU) with iterative reconstruction (IR) with that of conventional CTU.
MATERIALS AND METHODS: This prospective, multi-institutional, randomized controlled trial was performed at 16 hospitals using CT scanners from various vendors. Patients were randomly assigned to the following groups: 1) the LVLC-CTU (80 kVp and 240 mgI/mL) with IR group and 2) the conventional CTU (120 kVp and 350 mgI/mL) with filtered-back projection group. The overall diagnostic acceptability, sharpness, and noise were assessed. Additionally, the mean attenuation, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and figure of merit (FOM) in the urinary tract were evaluated.
RESULTS: The study included 299 patients (LVLC-CTU group: 150 patients: conventional CTU group: 149 patients). The LVLC-CTU group had a significantly lower effective radiation dose (5.73 +/- 4.04 vs. 8.43 +/- 4.38 mSv) compared to the conventional CTU group. LVLC-CTU showed at least standard diagnostic acceptability (score >/= 3), but it was non-inferior when compared to conventional CTU. The mean attenuation value, mean SNR, CNR, and FOM in all pre-defined segments of the urinary tract were significantly higher in the LVLC-CTU group than in the conventional CTU group.
CONCLUSION: The diagnostic acceptability and quantitative image quality of LVLC-CTU with IR are not inferior to those of conventional CTU. Additionally, LVLC-CTU with IR is beneficial because both radiation exposure and total iodine load are reduced.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHContrast Media/chemistry-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImage Interpretation, Computer-Assisted-
dc.subject.MESHIodine/chemistry-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProspective Studies-
dc.subject.MESHSignal-To-Noise Ratio-
dc.subject.MESHTomography, X-Ray Computed/instrumentation-
dc.subject.MESHTomography, X-Ray Computed/methods-
dc.subject.MESHUrinary Tract/diagnostic imaging-
dc.subject.MESHUrography/methods-
dc.subject.MESHYoung Adult-
dc.titleLow-Tube-Voltage CT Urography Using Low-Concentration-Iodine Contrast Media and Iterative Reconstruction: A Multi-Institutional Randomized Controlled Trial for Comparison with Conventional CT Urography-
dc.typeArticle-
dc.identifier.pmid30386143-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201985/-
dc.subject.keywordComputed tomography-
dc.subject.keywordLow dose-
dc.subject.keywordUrography-
dc.subject.keywordContrast media-
dc.subject.keywordDouble dose reduction-
dc.contributor.affiliatedAuthor이, 은주-
dc.type.localJournal Papers-
dc.identifier.doi10.3348/kjr.2018.19.6.1119-
dc.citation.titleKorean journal of radiology-
dc.citation.volume19-
dc.citation.number6-
dc.citation.date2018-
dc.citation.startPage1119-
dc.citation.endPage1129-
dc.identifier.bibliographicCitationKorean journal of radiology, 19(6). : 1119-1129, 2018-
dc.identifier.eissn2005-8330-
dc.relation.journalidJ012296929-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
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