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Ubiquitin C-terminal Hydrolase L1 Regulates Lipid Raft-dependent Endocytosis

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dc.contributor.authorKang, SJ-
dc.contributor.authorKim, JS-
dc.contributor.authorPark, SM-
dc.date.accessioned2019-11-13T00:21:04Z-
dc.date.available2019-11-13T00:21:04Z-
dc.date.issued2018-
dc.identifier.issn1226-2560-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/17312-
dc.description.abstractUbiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is highly expressed in neurons, and gathering evidence indicates that UCH-L1 may play pathogenic roles in many neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease (PD). Additionally, lipid rafts have attracted interest in neurodegeneration as playing a common role in many neurodegenerative diseases. In the present study, we demonstrated that UCH-L1 associates with lipid rafts as with other PD-associated gene products. In addition, UCH-L1 regulates lipid raft-dependent endocytosis and it is not dependent on the expression and degradation of caveolin-1 or flotillin-1. Finally, UCH-L1 regulates cell-to-cell transmission of alpha-synuclein. This study provides evidence that many PD-associated gene products share common signaling pathways to explain the pathogenesis of PD.-
dc.language.isoen-
dc.titleUbiquitin C-terminal Hydrolase L1 Regulates Lipid Raft-dependent Endocytosis-
dc.typeArticle-
dc.identifier.pmid30429647-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221840/-
dc.subject.keywordParkinson's disease-
dc.subject.keywordUCH-L1-
dc.subject.keywordalpha-synuclein-
dc.subject.keywordprion disease-
dc.contributor.affiliatedAuthor박, 상면-
dc.type.localJournal Papers-
dc.identifier.doi10.5607/en.2018.27.5.377-
dc.citation.titleExperimental neurobiology-
dc.citation.volume27-
dc.citation.number5-
dc.citation.date2018-
dc.citation.startPage377-
dc.citation.endPage386-
dc.identifier.bibliographicCitationExperimental neurobiology, 27(5). : 377-386, 2018-
dc.identifier.eissn2093-8144-
dc.relation.journalidJ012262560-
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Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
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