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Correlations between intravoxel incoherent motion diffusion-weighted MR imaging parameters and (18)F-FDG PET/CT metabolic parameters in patients with vertebral bone metastases: initial experience

Authors
Park, S  | Yoon, JK  | Chung, NS  | Kim, SH  | Hwang, J | Lee, HY | Kwack, KS
Citation
The British journal of radiology, 91(1086). : 20170889-20170889, 2018
Journal Title
The British journal of radiology
ISSN
0007-12851748-880X
Abstract
OBJECTIVE: To investigate the relationship between intravoxel incoherent motion (IVIM) diffusion-weighted MRI (DW MRI) parameters and (18)F-fluodeoxyglucose (FDG) (PET/CT) metabolic parameters in patients with vertebral bone metastases.
METHODS: 19 patients with vertebral bone metastases were retrospectively included in this institutional review board-approved study. All patients underwent IVIM DW-MRI and (18)F-FDG PET/CT before treatment. The IVIM parameters [molecular diffusion coefficient (D), perfusion fraction (f), and perfusion-related D (D*)] and apparent diffusion coefficient were acquired using 11 b-values (0, 10, 15, 20, 25, 50, 80, 120, 200, 300, and 800 s mm(-)(2)). Maximum and mean standardized uptake values (SUVmax and SUVmean, respectively), metabolic tumor volume, and total lesion glycolysis derived from (18)F-FDG PET/CT were calculated using thresholds of 3.0 SUV. The associations among parameters were evaluated by Spearman's correlation analysis.
RESULTS: A total of 19 patients and 41 regions of interest were included in this study. The IVIM parameter f was positively correlated with the metabolic parameters SUVmean and SUVmax [rho = 0.499 (p < 0.01) and rho = 0.413 (p < 0.01), respectively]. There was a weak positive correlation between D* and SUVmean (rho = 0.321, p = 0.041).
CONCLUSION: IVIM perfusion-related parameters, especially f, were correlated with (18)F-FDG PET/CT metabolic parameters in patients with vertebral bone metastases. IVIM DW-MRI, used to evaluate metabolic activity, appears to have diagnostic potential for bone metastasis and may also have utility in monitoring the post-treatment response.
Advances in knowledge: The use of IVIM for vertebral bone metastasis is demonstrated. f may be more suitable to reflect the metabolic activity and may facilitate another diagnostic potential for monitoring the posttreatment response.
MeSH

DOI
10.1259/bjr.20170889
PMID
29509489
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
Journal Papers > School of Medicine / Graduate School of Medicine > Nuclear Medicine & Molecular Imaging
Journal Papers > School of Medicine / Graduate School of Medicine > Orthopedic Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Neurosurgery
Ajou Authors
곽, 규성  |  김, 상현  |  박, 성훈  |  윤, 준기  |  정, 남수
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