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LTP induction modifies functional relationship among hippocampal neurons.

Authors
Yun, SH; Lee, DS; Lee, H; Baeg, EH; Kim, YB; Jung, MW
Citation
Learning & memory (Cold Spring Harbor, N.Y.), 14(3):190-194, 2007
Journal Title
Learning & memory (Cold Spring Harbor, N.Y.)
ISSN
1072-05021549-5485
Abstract
To obtain evidence linking long-term potentiation (LTP) and memory, we examined whether LTP induction modifies functional relationship among neurons in the rat hippocampus. In contrast to neurons in low-frequency stimulated or AP5-treated slices, LTP induction altered 'functional connectivity,' as defined by the degree of synchronous firing, among simultaneously recorded neurons in the CA3 region. Interestingly, functional connectivity changed bidirectionally so that the total sum of functional connectivity remained constant. These results demonstrate LTP-induced changes in neuronal functional connectivity and suggest the existence of a normalization mechanism for the total sum of functional connectivity.
MeSH terms
2-Amino-5-phosphonovalerate/pharmacologyAction PotentialsAnimalsElectric StimulationHippocampus/cytologyHippocampus/drug effectsHippocampus/physiology*Long-Term Potentiation/physiology*MaleNerve Net/physiology*Neurons/physiology*RatsRats, Sprague-Dawley
DOI
10.1101/lm.466307
PMID
17351143
Appears in Collections:
Journal Papers > Research Organization > Institute for Medical Sciences
AJOU Authors
정, 민환
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