100 263

Cited 0 times in

Stress-induced alterations in hippocampal plasticity, place cells, and spatial memory.

Authors
Kim, JJ; Lee, HJ; Welday, AC; Song, E; Cho, J; Sharp, PE; Jung, MW; Blair, HT
Citation
Proceedings of the National Academy of Sciences of the United States of America, 104(46):18297-18302, 2007
Journal Title
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-84241091-6490
Abstract
Acute, inescapable, and unpredictable stress can profoundly modify brain and cognition in humans and animals. The present study investigated the ensuing effects of 2-h variable "audiogenic" stress on three related levels of hippocampal functions in rats: long-term potentiation, place cell activity, and spatial memory. In agreement with prior findings, we observed that stress reduced the magnitude of Schaffer collateral/commissural-Cornu Ammonis field 1 long-term potentiation in vitro, and selectively impaired spatial memory on a hidden platform version of the Morris water maze task. We also observed that stress impaired the stability of firing rates (but not firing locations) of place cells recorded from dorsal Cornu Ammonis field 1 in rats foraging freely on a novel open-field platform located in a familiar surrounding room. These findings suggest that stress-induced modifications in synaptic plasticity may prevent the storage of stable "rate maps" by hippocampal place cells, which in turn may contribute to spatial memory impairments associated with stress.
MeSH terms
AnimalsExcitatory Postsynaptic PotentialsLong-Term PotentiationMaleMemory*Neuronal Plasticity*RatsRats, Long-EvansStress, Physiological/pathology*Stress, Physiological/physiopathology
DOI
10.1073/pnas.0708644104
PMID
17984057
Appears in Collections:
Journal Papers > Research Organization > Institute for Medical Sciences
AJOU Authors
정, 민환
Full Text Link
Files in This Item:
18297-18302.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse