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BRAF(wild) papillary thyroid carcinoma has two distinct mRNA expression patterns with different clinical behaviors

Authors
Kim, HK  | Lee, I  | Lee, J  | Chang, HS | Soh, EY  | Park, IS | Kim, JH | Rho, YS | Lee, DJ
Citation
Head & neck, 40(8). : 1707-1718, 2018
Journal Title
Head & neck
ISSN
1043-30741097-0347
Abstract
BACKGROUND: Using a large set of genomic data from The Cancer Genome Atlas (TCGA), we classified BRAF(wild) papillary thyroid carcinomas (PTCs) into 2 subtypes with distinct molecular patterns and different clinical behaviors. We also suggested gene signatures (RAS-score) to predict molecular subtypes and clinical behaviors of BRAF(wild) PTC.
METHOD: Integrated genomic analysis was done using all genomic data of PTC in TCGA data portal (https://tcga-data.nci.nih.gov) and cancer browser (https://genome-cancer.ucsc.edu). Using Gene Ontology and a logistic regression test, we selected gene signatures (RAS-score) and applied this prediction model to the validation cohort (GSE60542).
RESULT: When we performed multiplatform genomic analysis, BRAF(wild) PTCs were divided into 2 molecular subtypes. Each subtype showed distinct molecular patterns and clinical behaviors. Gene signatures successfully predicted molecular subtype in another validation cohort.
CONCLUSION: We found that BRAF(wild) PTCs were divided into 2 molecular subtypes and each subtype showed distinct molecular patterns, different activated pathways, and different clinical behaviors.
Keywords
DOI
10.1002/hed.25151
PMID
29573027
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Ajou Authors
김, 형규  |  소, 의영  |  이, 인화  |  이, 정훈
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