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Adjuvant concurrent chemoradiation therapy in patients with microscopic residual tumor after curative resection for extrahepatic cholangiocarcinoma

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dc.contributor.authorLee, J-
dc.contributor.authorKang, SH-
dc.contributor.authorNoh, OK-
dc.contributor.authorChun, M-
dc.contributor.authorOh, YT-
dc.contributor.authorKim, BW-
dc.contributor.authorKim, SW-
dc.date.accessioned2019-11-13T04:27:09Z-
dc.date.available2019-11-13T04:27:09Z-
dc.date.issued2018-
dc.identifier.issn1699-048X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/17535-
dc.description.abstractPURPOSE: We investigated the role of adjuvant concurrent chemoradiation therapy (CCRT) in patients with a microscopically positive resection margin (R1) after curative resection for extrahepatic cholangiocarcinoma (EHCC).
METHODS/PATIENTS: A total of 84 patients treated with curative resection for EHCC were included. Fifty-two patients with negative resection margins did not receive any adjuvant treatments (R0 + S group). The remaining 32 patients with microscopically positive resection margins received either adjuvant CCRT (R1 + CCRT group, n = 19) or adjuvant radiation therapy (RT) alone (R1 + RT group, n = 13).
RESULTS: During the median follow-up period of 26 months, the 2-year locoregional recurrence-free survival (LRRFS), disease-free survival (DFS), and overall survival rates (OS) were: 81.8, 62.6, and 61.5% for R0 + S group: 71.8, 57.8, and 57.9% for R1 + CCRT group: and 16.8, 9.6, and 15.4% for R1 + RT group, respectively. Multivariate analysis revealed that the R1 + CCRT group did not show any significant difference in survival rates compared with the R0 + S group. The R1 + RT group had lower LRRFS [hazard ratio (HR) 3.008: p = 0.044], DFS (HR 2.364: p = 0.022), and OS (HR 2.417: p = 0.011) when compared with the R0 + S and R1 + CCRT group.
CONCLUSIONS: A lack of significant survival difference between R0 + S group and R1 + CCRT group suggests that adjuvant CCRT ameliorates the negative effect of microscopic positive resection margin. In contrast, adjuvant RT alone is appeared to be inadequate for controlling microscopically residual tumor.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBile Duct Neoplasms-
dc.subject.MESHChemoradiotherapy-
dc.subject.MESHChemoradiotherapy, Adjuvant-
dc.subject.MESHCholangiocarcinoma-
dc.subject.MESHCombined Modality Therapy-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Recurrence, Local-
dc.subject.MESHNeoplasm, Residual-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSurvival Rate-
dc.titleAdjuvant concurrent chemoradiation therapy in patients with microscopic residual tumor after curative resection for extrahepatic cholangiocarcinoma-
dc.typeArticle-
dc.identifier.pmid29256155-
dc.subject.keywordExtrahepatic cholangiocarcinoma-
dc.subject.keywordConcurrent chemoradiation therapy-
dc.subject.keywordPositive surgical margin-
dc.subject.keywordSurvival-
dc.contributor.affiliatedAuthor노, 오규-
dc.contributor.affiliatedAuthor전, 미선-
dc.contributor.affiliatedAuthor오, 영택-
dc.contributor.affiliatedAuthor김, 봉완-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s12094-017-1815-y-
dc.citation.titleClinical & translational oncology-
dc.citation.volume20-
dc.citation.number8-
dc.citation.date2018-
dc.citation.startPage1011-
dc.citation.endPage1017-
dc.identifier.bibliographicCitationClinical & translational oncology, 20(8). : 1011-1017, 2018-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1699-3055-
dc.relation.journalidJ01699048X-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Radiation Oncology
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
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