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Nonalcoholic fatty liver disease as a sentinel marker for the development of diabetes mellitus in non-obese subjects

Kim, SS  | Cho, HJ  | Kim, HJ | Kang, DR | Berry, JR | Kim, JH  | Yang, MJ  | Lim, SG  | Kim, S | Cheong, JY  | Cho, SW
Digestive and liver disease, 50(4). : 370-377, 2018
Journal Title
Digestive and liver disease
BACKGROUND: Non alcoholic fatty liver disease (NAFLD) is associated with substantial cardiometabolic morbidity.
AIMS: We evaluated the long-term extrahepatic complications of NAFLD and sought to evaluate NAFLD in non-obese subjects.
METHODS: A total of 2920 participants were retrospectively selected from a health check-up center in 2000, and followed through to December 2010. NAFLD was diagnosed using ultrasonography. Subjects were stratified according to body mass index, NAFLD, and metabolic syndrome.
RESULTS: The prevalence of non-obese NAFLD subjects and metabolically unhealthy non-obese subjects was 14.4% and 8.7%, respectively. In the multivariate analysis, non-obese NAFLD subjects had a significantly higher risk for diabetes mellitus (DM: HR 2.69, 95% CI 1.72-4.20, P<0.001): no increase was observed for hypertension or cardiovascular disease. Metabolically unhealthy non-obese subjects had a significantly higher risk for hypertension (HR 2.75, 95% CI 2.02-3.74, P<0.001), DM (HR 5.72, 95% CI 3.68-8.89, P<0.001), and cardiovascular disease (HR 2.93, 95% CI 1.53-5.63, P=0.001). Subgroup analysis of non-obese subjects showed that NAFLD, without metabolic syndrome, conferred a higher risk for DM (HR 3.60, 95% CI 2.03-6.39, P<0.001).
CONCLUSION: Non-obese subjects with NAFLD are at a higher risk for DM independent of metabolic syndrome.


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Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Ajou Authors
김, 순선  |  김, 진홍  |  양, 민재  |  임, 선교  |  정, 재연  |  조, 성원  |  조, 효정
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