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10-Year Outcomes of Stents Versus Coronary Artery Bypass Grafting for Left Main Coronary Artery Disease

Authors
Park, DW | Ahn, JM | Yun, SC | Yoon, YH | Kang, DY | Lee, PH | Lee, SW | Park, SW | Seung, KB | Gwon, HC | Jeong, MH | Jang, Y | Kim, HS | Seong, IW | Park, HS | Ahn, T | Chae, IH | Tahk, SJ  | Park, SJ
Citation
Journal of the American College of Cardiology, 72(23 Pt A). : 2813-2822, 2018
Journal Title
Journal of the American College of Cardiology
ISSN
0735-10971558-3597
Abstract
BACKGROUND: Comparative outcomes of coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) for left main coronary artery (LMCA) disease were previously reported. However, data on very long-term (>10 years) outcomes are limited.
OBJECTIVES: The authors compare 10-year outcomes after PCI and CABG for LMCA disease.
METHODS: In this observational study of the MAIN-COMPARE (Revascularization for Unprotected Left Main Coronary Artery Stenosis: Comparison of Percutaneous Coronary Angioplasty versus Surgical Revascularization) registry, the authors evaluated 2,240 patients with unprotected LMCA disease who underwent PCI (n = 1,102) or underwent CABG (n = 1,138) between January 2000 and June 2006. Adverse outcomes (death: a composite outcome of death, Q-wave myocardial infarction, or stroke: and target-vessel revascularization) were compared with the use of propensity scores and inverse-probability-weighting adjustment. The follow-up was extended to at least 10 years of all patients (median 12.0 years).
RESULTS: In the overall cohort, there was no significant difference in adjusted risks of death and the composite outcome between the groups up to 10 years. The risk of target-vessel revascularization was significantly higher in the PCI group. In the cohort comparing drug-eluting stents and concurrent CABG, the 2 study groups did not differ significantly in the risks of death and the composite outcome at 5 years. However, after 5 years, drug-eluting stents were associated with higher risks of death (hazard ratio: 1.35: 95% confidence interval: 1.00 to 1.81) and the composite outcome (hazard ratio: 1.46: 95% confidence interval: 1.10 to 1.94) compared with CABG.
CONCLUSIONS: In patients with significant LMCA disease, as compared with CABG, PCI showed similar rates of death and serious composite outcomes, but a higher rate of target-vessel revascularization at 10 years. However, CABG showed lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years. (Revascularization for Unprotected Left Main Coronary Artery Stenosis: Comparison of Percutaneous Coronary Angioplasty versus Surgical Revascularization [MAIN-COMPARE]: NCT02791412).
Keywords
DOI
10.1016/j.jacc.2018.09.012
PMID
30261236
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
Ajou Authors
탁, 승제
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