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Comparative analyses of nilotinib versus high-dose imatinib versus sustained standard-dose imatinib in patients with chronic phase chronic myeloid leukemia following suboptimal molecular response to first-line imatinib

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dc.contributor.authorLee, SE-
dc.contributor.authorChoi, SY-
dc.contributor.authorKim, SH-
dc.contributor.authorJootar, S-
dc.contributor.authorKim, HJ-
dc.contributor.authorSohn, SK-
dc.contributor.authorPark, JS-
dc.contributor.authorKim, SH-
dc.contributor.authorZang, DY-
dc.contributor.authorOh, SJ-
dc.contributor.authorKim, DW-
dc.date.accessioned2019-11-13T04:27:42Z-
dc.date.available2019-11-13T04:27:42Z-
dc.date.issued2018-
dc.identifier.issn0145-2126-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/17608-
dc.description.abstractThe aim of this study was to investigate the efficacy of nilotinib (NIL) versus high-dose imatinib (IM) versus sustained standard-dose IM for patients with chronic myeloid leukemia (CML) with suboptimal molecular response to first-line IM therapy. Patients with CML who achieved complete cytogenetic response (CCyR) but not major molecular response (MMR) after 18-24 months on first-line IM therapy were enrolled and divided into three treatment cohorts: NIL 800mg/day (Cohort 1, n=28) and IM 800mg/day (Cohort 2, n=28) in the RE-NICE study, and sustained IM 400mg/day (Cohort 3, n=52) in clinical practice. The primary efficacy variable of cumulative rate of MMR by 12 months was not different among the three cohorts. However, the cumulative incidence of MMR by 36 months was significantly higher in Cohort 1 than Cohort 3 (83.1% vs. 57.1%, P=0.021), but there were no significant differences in Cohort 1 vs. 2 (P=0.195) and Cohort 2 vs. 3 (P=0.297). Different profile for adverse events was observed between NIL and high-dose IM therapy. In conclusion, our data suggested that switching to NIL may provide more effective long-term response than sustaining standard-dose IM for patients with suboptimal molecular response to first-line IM.-
dc.language.isoen-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntineoplastic Agents-
dc.subject.MESHBiomarkers, Tumor-
dc.subject.MESHCytogenetic Analysis-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImatinib Mesylate-
dc.subject.MESHLeukemia, Myeloid, Chronic-Phase-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMolecular Targeted Therapy-
dc.subject.MESHProtein Kinase Inhibitors-
dc.subject.MESHRetreatment-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleComparative analyses of nilotinib versus high-dose imatinib versus sustained standard-dose imatinib in patients with chronic phase chronic myeloid leukemia following suboptimal molecular response to first-line imatinib-
dc.typeArticle-
dc.identifier.pmid29908417-
dc.subject.keywordChronic myeloid leukemia-
dc.subject.keywordSuboptimal response-
dc.subject.keywordNilotinib-
dc.subject.keywordImatinib-
dc.contributor.affiliatedAuthor박, 준성-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.leukres.2018.06.002-
dc.citation.titleLeukemia research-
dc.citation.volume70-
dc.citation.date2018-
dc.citation.startPage100-
dc.citation.endPage105-
dc.identifier.bibliographicCitationLeukemia research, 70. : 100-105, 2018-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1873-5835-
dc.relation.journalidJ001452126-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
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