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Expression of EpCAM in adenoid cystic carcinoma

DC Field Value Language
dc.contributor.authorLee, SJ-
dc.contributor.authorChung, KY-
dc.contributor.authorKwon, JE-
dc.contributor.authorYoon, SO-
dc.contributor.authorKim, SK-
dc.date.accessioned2019-11-13T04:27:44Z-
dc.date.available2019-11-13T04:27:44Z-
dc.date.issued2018-
dc.identifier.issn0031-3025-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/17614-
dc.description.abstractThe mutational landscape of adenoid cystic carcinoma (ACC) is currently being revealed, but further studies are needed to identify biomarkers as therapeutic targets or prognostic factors of ACC. In this study, we investigated the expression of epithelial cell adhesion molecule (EpCAM) in ACCs. We retrospectively collected 83 cases of surgically resected ACCs. Using tissue microarray, we conducted immunohistochemical staining using the anti-EpCAM antibody. EpCAM expression was analysed by intensity score and the total immunostaining score. The positivity was 97.6% (81/83 cases), regardless of the intensity score. A higher histological grade (p = 0.006) and specific tumour location (non-salivary gland origin, p = 0.02) showed a correlation with higher EpCAM intensity. Higher EpCAM expression by total immunostaining score was associated with histological grade (p = 0.004), distant metastasis (p = 0.004) and poorer prognosis (overall survival p = 0.015 and progression-free survival p = 0.033). We suggest EpCAM as a candidate prognostic marker and a putative therapeutic target in ACC. Also, ACCs arising from salivary gland and non-salivary gland sites, respectively, might display different pathophysiologies in which EpCAM could play a role.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBiomarkers/metabolism-
dc.subject.MESHCarcinoma, Adenoid Cystic/diagnosis-
dc.subject.MESHCarcinoma, Adenoid Cystic/metabolism-
dc.subject.MESHCarcinoma, Adenoid Cystic/pathology-
dc.subject.MESHEpithelial Cell Adhesion Molecule/genetics-
dc.subject.MESHEpithelial Cell Adhesion Molecule/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Metastasis-
dc.subject.MESHPrognosis-
dc.subject.MESHProgression-Free Survival-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSalivary Gland Neoplasms/diagnosis-
dc.subject.MESHSalivary Gland Neoplasms/metabolism-
dc.subject.MESHSalivary Gland Neoplasms/pathology-
dc.subject.MESHSalivary Glands/metabolism-
dc.subject.MESHSalivary Glands/pathology-
dc.subject.MESHTissue Array Analysis-
dc.subject.MESHYoung Adult-
dc.titleExpression of EpCAM in adenoid cystic carcinoma-
dc.typeArticle-
dc.identifier.pmid30389218-
dc.subject.keywordAdenoid cystic carcinoma-
dc.subject.keywordEpCAM-
dc.subject.keywordBer-EP4-
dc.subject.keywordbiomarker-
dc.subject.keywordnonsalivary gland-
dc.contributor.affiliatedAuthor권, 지은-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.pathol.2018.08.013-
dc.citation.titlePathology-
dc.citation.volume50-
dc.citation.number7-
dc.citation.date2018-
dc.citation.startPage737-
dc.citation.endPage741-
dc.identifier.bibliographicCitationPathology, 50(7). : 737-741, 2018-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1465-3931-
dc.relation.journalidJ000313025-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
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