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Clinical Implication of Tests for Prostate-specific Antigen in Brain-dead Organ Donors

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dc.contributor.authorLee, GW-
dc.contributor.authorLee, JM-
dc.contributor.authorLee, WJ-
dc.contributor.authorKim, YB-
dc.contributor.authorMin, YG-
dc.date.accessioned2019-11-13T04:27:51Z-
dc.date.available2019-11-13T04:27:51Z-
dc.date.issued2018-
dc.identifier.issn0041-1345-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/17624-
dc.description.abstractBACKGROUND: Although cancer screening tests are not mentioned under brain-dead organ donor care guidelines in Korea, we assessed the level of prostate-specific antigen (PSA), an important prostate cancer marker, and performed prostate biopsies when needed in brain-dead organ donors. We believe that insisting on a screening test for cancer diagnosis in donors' organs is important.
MATERIALS AND METHODS: Data were collected between January 2010 and July 2015 from Ajou University Hospital. We retrospectively analyzed the PSA levels and prostate biopsy results in 111 male brain-dead organ donors (mean age, 48.4 years).
RESULTS: The mean PSA level was 7.395 ng/mL (range, 0.062 to 61.780: reference, 0 to 4 ng/mL). Ultrasonography or computed tomographic examination did not reveal prostate cancer, and a rectal examination was not performed. After checking the PSA levels, prostate biopsies were performed in 16 patients based on the recommendations of a urologist, and 4 patients (3.6% of 111) were diagnosed with prostate cancer. All cancers involved adenocarcinomas (acinar type) histopathologically. In 2 patients, the Gleason score was 6 (3 + 3), whereas the other 2 showed a score of 7 (3 + 4). Among the patients diagnosed with prostate cancer, 1 donated his liver and corneas, and the remaining 3 could not donate.
CONCLUSION: Well-defined cancer screening tests are needed in Korea. Additionally, when the probability of organ transplantation-induced cancer metastasis is low or a recipient is at a high risk owing to not receiving organs, the law should allow organ donation even if prostate cancer is diagnosed in the donor.
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dc.language.isoen-
dc.subject.MESHAdenocarcinoma-
dc.subject.MESHAged-
dc.subject.MESHBiopsy-
dc.subject.MESHBrain Death-
dc.subject.MESHEarly Detection of Cancer-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Grading-
dc.subject.MESHProstate-
dc.subject.MESHProstate-Specific Antigen-
dc.subject.MESHProstatic Neoplasms-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTissue Donors-
dc.subject.MESHTissue and Organ Procurement-
dc.titleClinical Implication of Tests for Prostate-specific Antigen in Brain-dead Organ Donors-
dc.typeArticle-
dc.identifier.pmid29407309-
dc.contributor.affiliatedAuthor김, 영배-
dc.contributor.affiliatedAuthor민, 영기-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.transproceed.2017.11.015-
dc.citation.titleTransplantation proceedings-
dc.citation.volume50-
dc.citation.number1-
dc.citation.date2018-
dc.citation.startPage20-
dc.citation.endPage23-
dc.identifier.bibliographicCitationTransplantation proceedings, 50(1). : 20-23, 2018-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1873-2623-
dc.relation.journalidJ000411345-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Emergency Medicine
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