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Three-Year Recurrence-Free Survival in Patients With a Very Low Risk of Endometrial Cancer Who Did Not Undergo Lymph Node Dissection (Tree Retro): A Korean Multicenter Study

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dc.contributor.authorKim, M-
dc.contributor.authorChoi, C-
dc.contributor.authorKim, K-
dc.contributor.authorLim, MC-
dc.contributor.authorPark, JY-
dc.contributor.authorHong, JH-
dc.contributor.authorLee, M-
dc.contributor.authorPaek, J-
dc.contributor.authorSeoung, J-
dc.contributor.authorLee, S-
dc.contributor.authorLee, TS-
dc.date.accessioned2019-11-13T04:28:08Z-
dc.date.available2019-11-13T04:28:08Z-
dc.date.issued2018-
dc.identifier.issn1048-891X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/17664-
dc.description.abstractOBJECTIVE: Randomized studies have not demonstrated a survival benefit of routine lymph node dissection in early-stage endometrial cancer. Many surgeons nevertheless perform lymph node dissection in all patients with early-stage endometrial cancer. This study aimed to ascertain the survival outcomes of very low-risk endometrial cancer patients (by the Korean Gynecologic Oncology Group [KGOG] criteria) who did not undergo lymph node dissection.
MATERIALS AND METHODS: Medical records of 156 consecutive patients who underwent surgical staging without lymph node dissection were collected from 10 institutions. All patients fulfilled the KGOG criteria: (1) endometrioid corpus cancer diagnosed by preoperative endometrial biopsy, (2) serum cancer antigen-125 level /=1.0 cm by MRI or computed tomography. Sampling of <5 nodes was allowed at a surgeon's discretion. We evaluated the 3-year recurrence-free survival (RFS) and 5-year overall survival (OS) using the Kaplan-Meier method.
RESULTS: The median patient age was 52 years (range, 24-86 years). The median follow-up was 59 months (range, 0-189 months). The 3-year RFS and 5-year OS were 98.6% (95% confidence interval [CI], 96.8%-100.0%) and 98.6% (95% CI, 96.7%-100.0%), respectively. No disease-related mortality occurred. The final pathology report revealed >/=50% myometrial invasion in 29 patients (18.6%) and extension beyond the uterine corpus in 2 patients (1.3%). One patient (0.6%) was diagnosed with lymph node metastasis after lymph node sampling. Eighteen patients (11.5%) received adjuvant therapy after the final pathologic results indicated high risk.
CONCLUSIONS: Very low-risk patients who did not undergo lymph node dissection had acceptable survival outcomes. Omitting lymph node dissection may be reasonable in patients satisfying the KGOG criteria.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCohort Studies-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHEndometrial Neoplasms-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHysterectomy-
dc.subject.MESHLymph Node Excision-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Recurrence, Local-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHSalpingo-oophorectomy-
dc.subject.MESHYoung Adult-
dc.titleThree-Year Recurrence-Free Survival in Patients With a Very Low Risk of Endometrial Cancer Who Did Not Undergo Lymph Node Dissection (Tree Retro): A Korean Multicenter Study-
dc.typeArticle-
dc.identifier.pmid29664841-
dc.subject.keywordEndometrial cancer-
dc.subject.keywordLymph node dissection-
dc.subject.keywordLow risk-
dc.subject.keywordRecurrence-free survival-
dc.contributor.affiliatedAuthor백, 지흠-
dc.type.localJournal Papers-
dc.identifier.doi10.1097/IGC.0000000000001270-
dc.citation.titleInternational journal of gynecological cancer-
dc.citation.volume28-
dc.citation.number6-
dc.citation.date2018-
dc.citation.startPage1123-
dc.citation.endPage1129-
dc.identifier.bibliographicCitationInternational journal of gynecological cancer, 28(6). : 1123-1129, 2018-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1525-1438-
dc.relation.journalidJ01048891X-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
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