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Photodynamic therapy inhibits melanogenesis through paracrine effects by keratinocytes and fibroblasts

Authors
Kim, SK; Oh, SJ; Park, SY; Kim, WJ; Kim, YS; Kim, YC
Citation
Pigment cell & melanoma research, 31(2):277-286, 2018
Journal Title
Pigment cell & melanoma research
ISSN
1755-14711755-148X
Abstract
Photodynamic therapy (PDT) is a treatment option for skin cancer and premalignant skin diseases and exhibits rejuvenation effects, including reducing fine wrinkles and whitening, on aged skin. In this study, we investigated the mechanism underlying the whitening effects of PDT on melanocytes (MCs) in vitro and in vivo. Exposure of MCs to PDT in vitro reduced their melanin content and tyrosinase activity without, however, affecting cell survival. Interestingly, melanogenesis was also inhibited by exposing MCs to conditioned media of PDT-treated keratinocytes or dermal fibroblasts. This paracrine effect was likely due to a decreased release of melanocyte-stimulating cytokines such as Kit ligand and hepatocyte growth factor from these cells. Furthermore, we observed that PDT reduced mottled hyperpigmentation of photoaged patient skin in vivo, highlighting the clinical importance of skin whitening by PDT.
Keywords
melanocytesmelanogenesisparacrine communicationphotodynamic therapyrejuvenation
MeSH terms
AnimalsCattleCulture Media, Conditioned/pharmacologyCytokines/metabolismExtracellular Signal-Regulated MAP Kinases/metabolismFibroblasts/metabolism*HumansHyperpigmentation/metabolismInfant, NewbornKeratinocytes/drug effectsKeratinocytes/metabolism*Melanins/biosynthesis*Melanocytes/drug effectsMelanocytes/enzymologyMicrophthalmia-Associated Transcription Factor/metabolismMonophenol Monooxygenase/metabolismParacrine Communication*/drug effectsPhosphorylation/drug effectsPhotochemotherapy*Skin/pathology
DOI
10.1111/pcmr.12658
PMID
29045012
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
AJOU Authors
김, 유선김, 유찬
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