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Benefit of Prolonged Dual Antiplatelet Therapy After Implantation of Drug-Eluting Stent for Coronary Bifurcation Lesions: Results From the Coronary Bifurcation Stenting Registry II

Authors
Jang, WJ; Ahn, SG; Song, YB; Choi, SH; Chun, WJ; Oh, JH; Cho, SW; Kim, BS; Yoon, JH; Koo, BK; Yu, CW; Jang, YS; Tahk, SJ; Kim, HS; Gwon, HC; Lee, SY; Hahn, JY
Citation
Circulation. Cardiovascular interventions, 11(7):e005849-e005849, 2018
Journal Title
Circulation. Cardiovascular interventions
ISSN
1941-76401941-7632
Abstract
BACKGROUND: Whether prolonged dual antiplatelet therapy (DAPT) improves clinical outcomes after percutaneous coronary intervention for coronary bifurcation lesion is uncertain.
METHODS AND RESULTS: We evaluated 2082 patients who were treated with drug-eluting stent for bifurcation lesions and were event free (no death, myocardial infarction [MI], cerebrovascular accident, stent thrombosis, or any revascularization) at 12 months after the index procedure. Patients were divided into 2 groups: DAPT >/=12-month group (n=1776) and DAPT /=12-month group than the DAPT <12-month group (2.8% versus 12.3%: adjusted hazard ratio, 0.21: 95% confidence interval, 0.13-0.35: P/=12-month group than the DAPT <12-month group (2.6% versus 12.3%: adjusted hazard ratio, 0.22: 95% confidence interval, 0.12-0.38: P/=12-month DAPT group than the <12-month DAPT group after percutaneous coronary intervention for bifurcation lesion using drug-eluting stent. Our results suggest that prolonged DAPT may improve long-term clinical outcomes after percutaneous coronary intervention for bifurcation lesions.
CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01642992.
Keywords
drug-eluting stentsincidencemyocardial infarctionpercutaneous coronary interventionthrombosis
MeSH terms
AgedCoronary Artery Disease/diagnostic imagingCoronary Artery Disease/mortalityCoronary Artery Disease/therapy*Coronary Thrombosis/mortalityCoronary Thrombosis/prevention & controlDrug Administration ScheduleDrug Therapy, CombinationDrug-Eluting Stents*FemaleHumansIncidenceMaleMiddle AgedMyocardial Infarction/mortalityMyocardial Infarction/prevention & controlPercutaneous Coronary Intervention/adverse effectsPercutaneous Coronary Intervention/instrumentation*Percutaneous Coronary Intervention/mortalityPlatelet Aggregation Inhibitors/administration & dosage*Platelet Aggregation Inhibitors/adverse effectsProgression-Free SurvivalRegistriesRepublic of Korea/epidemiologyRetrospective StudiesRisk AssessmentRisk FactorsStroke/mortalityStroke/prevention & controlTime Factors
DOI
10.1161/CIRCINTERVENTIONS.117.005849
PMID
30006330
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
AJOU Authors
탁, 승제
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