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Polyamine patterns in plasma of patients with systemic lupus erythematosus and fever

Authors
Kim, HA; Lee, HS; Shin, TH; Jung, JY; Baek, WY; Park, HJ; Lee, G; Paik, MJ; Suh, CH
Citation
Lupus, 27(6):930-938, 2018
Journal Title
Lupus
ISSN
0961-20331477-0962
Abstract
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with various clinical manifestations and serologic markers. In this study, we analyzed nine polyamine (PA) profiles of plasma from patients with SLE and healthy controls (HCs), and the relationship between the PA profiles and disease activity. PA alterations in plasma of 44 patients with SLE and fever were investigated using gas chromatography mass spectrometry (GC-MS) in selected ion monitoring mode using N-ethoxycarbonyl/ N-pentafluoropropionyl derivatives, and compared with those of 43 HCs. Patients with SLE and HCs showed differences in five of nine PA profiles. Among five changed PA levels, four PAs, namely N(1)-acetylcadaverine, spermidine, N(1)-acetylspermidine, and spermine, were dramatically decreased. However, the level of cadaverine was increased in patients with SLE. In the partial correlation with PA profiles and disease activity markers of SLE, several disease activity markers and nutritional markers were correlated with cadaverine, spermidine, and N (8)-acetylspermidine. Thus, our results provide a comprehensive understanding of the relationship between PA metabolomics and disease activity markers in patients with SLE.
Keywords
Systemic lupus erythematosuspolyaminebiomarkerdisease activity
MeSH terms
AdultBiomarkers/bloodCase-Control StudiesFemaleFever/blood*Fever/diagnosisGas Chromatography-Mass SpectrometryHumansLupus Erythematosus, Systemic/blood*Lupus Erythematosus, Systemic/diagnosisLupus Erythematosus, Systemic/physiopathologyMaleMetabolomics/methodsMiddle AgedNutritional StatusPolyamines/blood*Prospective StudiesSeverity of Illness IndexYoung Adult
DOI
10.1177/0961203317751860
PMID
29308729
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
AJOU Authors
김, 현아정, 주양이, 광서, 창희
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