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Associations Between PET Textural Features and GLUT1 Expression, and the Prognostic Significance of Textural Features in Lung Adenocarcinoma

Authors
Koh, YW; Park, SY; Hyun, SH; Lee, SJ
Citation
Anticancer research, 38(2):1067-1071, 2018
Journal Title
Anticancer research
ISSN
0250-70051791-7530
Abstract
BACKGROUND/AIM: We evaluated the association between positron emission tomography (PET) textural features and glucose transporter 1 (GLUT1) expression level and further investigated the prognostic significance of textural features in lung adenocarcinoma.
PATIENTS AND METHODS: We evaluated 105 adenocarcinoma patients. We extracted texture-based PET parameters of primary tumors. Conventional PET parameters were also measured. The relationships between PET parameters and GLUT1 expression levels were evaluated. The association between PET parameters and overall survival (OS) was assessed using Cox's proportional hazard regression models.
RESULTS: In terms of PET textural features, tumors expressing high levels of GLUT1 exhibited significantly lower coarseness, contrast, complexity, and strength, but significantly higher busyness. On univariate analysis, the metabolic tumor volume, total lesion glycolysis, contrast, busyness, complexity, and strength were significant predictors of OS. Multivariate analysis showed that lower complexity (HR=2.017, 95%CI=1.032-3.942, p=0.040) was independently associated with poorer survival.
CONCLUSION: PET textural features may aid risk stratification in lung adenocarcinoma patients.
Keywords
Non-small cell lung canceradenocarcinomaglucose transporter 1positron emission tomographytexture analysis
MeSH terms
Adenocarcinoma/diagnostic imagingAdenocarcinoma/metabolismAdenocarcinoma/pathology*AdultAgedAged, 80 and overBiomarkers, Tumor/metabolismCarcinoma, Non-Small-Cell Lung/diagnostic imagingCarcinoma, Non-Small-Cell Lung/metabolismCarcinoma, Non-Small-Cell Lung/pathology*Carcinoma, Squamous Cell/diagnostic imagingCarcinoma, Squamous Cell/metabolismCarcinoma, Squamous Cell/pathology*FemaleFluorodeoxyglucose F18Follow-Up StudiesGlucose Transporter Type 1/metabolism*HumansLung Neoplasms/diagnostic imagingLung Neoplasms/metabolismLung Neoplasms/pathology*MaleMiddle AgedPositron-Emission Tomography/methods*PrognosisRadiopharmaceuticalsRetrospective StudiesSurvival RateTomography, X-Ray Computed/methods
DOI
10.21873/anticanres.12324
PMID
29374742
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Nuclear Medicine & Molecular Imaging
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