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EpCAM as a Predictive Marker of Tumor Recurrence and Survival in Patients Who Underwent Surgical Resection for Hepatocellular Carcinoma

Authors
Noh, CK  | Wang, HJ  | Kim, CM | Kim, J | Yoon, SY  | Lee, GH  | Cho, HJ  | Yang, MJ  | Kim, SS  | Hwang, JC  | Cho, SW  | Roh, J  | Kim, YB  | Kim, SJ | Kim, BW  | Cheong, JY
Citation
Anticancer research, 38(7). : 4101-4109, 2018
Journal Title
Anticancer research
ISSN
0250-70051791-7530
Abstract
BACKGROUND/AIM: Epithelial cell adhesion molecule (EpCAM) is expressed in hepatic progenitor cells and hepatocellular carcinoma (HCC), and is considered a marker of liver cancer stem cells.
MATERIALS AND METHODS: A total of 262 patients were enrolled who had undergone surgical resection for HCC, with immunohistochemical staining results for EpCAM. The immunohistochemical expression of EpCAM and other stemness-related markers was evaluated as prognosticators of tumor recurrence and survival in patients who underwent surgical resection for HCC.
RESULTS: A multivariate Cox regression analysis showed that tumor size [hazard ratio (HR)=2.26, p=0.005], intrahepatic metastasis (HR=2.31, p=0.011), and EpCAM positivity (HR=1.74, p=0.038) were associated with tumor recurrence. In a Kaplan-Meier survival analysis, patients with EpCAM-positive tumors had a significantly higher tumor recurrence rate and a reduced overall survival compared to those with EpCAM-negative tumors.
CONCLUSION: Immunohistochemical expression of EpCAM was identified as a poor prognosticator of recurrence and survival after surgical resection in patients with HCC.
Keywords
MeSH

DOI
10.21873/anticanres.12700
PMID
29970536
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Ajou Authors
김, 봉완  |  김, 순선  |  김, 영배  |  노, 진  |  노, 충균  |  양, 민재  |  왕, 희정  |  윤, 소영  |  이, 길호  |  정, 재연  |  조, 성원  |  조, 효정  |  황, 재철
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