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EpCAM as a Predictive Marker of Tumor Recurrence and Survival in Patients Who Underwent Surgical Resection for Hepatocellular Carcinoma

Authors
Noh, CK; Wang, HJ; Kim, CM; Kim, J; Yoon, SY; Lee, GH; Cho, HJ; Yang, MJ; Kim, SS; Hwang, JC; Cho, SW; Roh, J; Kim, YB; Kim, SJ; Kim, BW; Cheong, JY
Citation
Anticancer research, 38(7):4101-4109, 2018
Journal Title
Anticancer research
ISSN
0250-70051791-7530
Abstract
BACKGROUND/AIM: Epithelial cell adhesion molecule (EpCAM) is expressed in hepatic progenitor cells and hepatocellular carcinoma (HCC), and is considered a marker of liver cancer stem cells.
MATERIALS AND METHODS: A total of 262 patients were enrolled who had undergone surgical resection for HCC, with immunohistochemical staining results for EpCAM. The immunohistochemical expression of EpCAM and other stemness-related markers was evaluated as prognosticators of tumor recurrence and survival in patients who underwent surgical resection for HCC.
RESULTS: A multivariate Cox regression analysis showed that tumor size [hazard ratio (HR)=2.26, p=0.005], intrahepatic metastasis (HR=2.31, p=0.011), and EpCAM positivity (HR=1.74, p=0.038) were associated with tumor recurrence. In a Kaplan-Meier survival analysis, patients with EpCAM-positive tumors had a significantly higher tumor recurrence rate and a reduced overall survival compared to those with EpCAM-negative tumors.
CONCLUSION: Immunohistochemical expression of EpCAM was identified as a poor prognosticator of recurrence and survival after surgical resection in patients with HCC.
Keywords
Epithelial cell adhesion moleculehepatocellular carcinomarecurrencesurgical resectionsurvival
MeSH terms
AdultAgedBiomarkers, Tumor/metabolism*Carcinoma, Hepatocellular/mortality*Carcinoma, Hepatocellular/pathologyCarcinoma, Hepatocellular/surgery*Epithelial Cell Adhesion Molecule/metabolism*FemaleHumansImmunohistochemistryLiver Neoplasms/mortality*Liver Neoplasms/pathologyLiver Neoplasms/surgery*MaleMiddle AgedNeoplasm Recurrence, Local/diagnosis*PrognosisSurvival Analysis
DOI
10.21873/anticanres.12700
PMID
29970536
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
AJOU Authors
노, 충균왕, 희정윤, 소영이, 길호조, 효정양, 민재김, 순선황, 재철조, 성원노, 진김, 영배김, 봉완정, 재연
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