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Effect of Cilostazol on Incident Dementia in Elderly Men and Women with Ischemic Heart Disease

Authors
Kim, MY; Noh, Y; Son, SJ; Shin, S; Paik, HY; Lee, S; Jung, YS
Citation
Journal of Alzheimer's disease : JAD, 63(2):635-644, 2018
Journal Title
Journal of Alzheimer's disease : JAD
ISSN
1387-28771875-8908
Abstract
BACKGROUND: Ischemic heart disease (IHD) is associated with cognitive decline and may contribute to an increased risk of dementia.
OBJECTIVE: The goal of the present study was to investigate whether cilostazol use is associated with a lower risk of incident dementia in Asian patients with IHD, and whether these effects differed based on sex.
METHODS: This retrospective cohort study was performed using the Korean National Insurance Claim Data of the Health Insurance Review and Assessment Service: the duration of the study was from January 1, 2007 to December 31, 2015. The study group comprised 66,225 patients with IHD, aged >65 years, who had received cilostazol. Age- and sex-matched IHD patients without cilostazol exposure were selected as the control group. The risk of dementia was compared between the cilostazol and control groups.
RESULTS: Compared to the control group, total cilostazol users had a marginally significant lower risk of incident dementia. After stratification by sex, the reducing effect of cilostazol on incident dementia was significant in female participants, but not in male participants. Female patients who had cilostazol for over 2 years showed a clinically meaningful preventive effect (HR, 0.85: 95% CI, 0.82-0.88).
CONCLUSIONS: This study suggested that cilostazol treatment may reduce the risk of incident dementia in Korean patients with IHD. Its beneficial effect was remarkably significant in female patients who received cilostazol for over a 2-year period.
Keywords
Cilostazoldementiaischemic heart diseasesex difference
MeSH terms
AgedAged, 80 and overCilostazol/therapeutic use*Cohort StudiesDementia/drug therapy*Dementia/epidemiologyFemaleHumansMaleMyocardial Ischemia/drug therapy*Myocardial Ischemia/epidemiologyMyocardial Ischemia/psychologyNootropic Agents/therapeutic use*Phosphodiesterase 3 Inhibitors/therapeutic use*Platelet Aggregation Inhibitors/therapeutic use*Risk FactorsSex Factors
DOI
10.3233/JAD-170895
PMID
29660935
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
AJOU Authors
손, 상준
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