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뇌종양 동물모델에서의 인간신경줄기세포주의 종양으로의 특이적 이주에 관한 입체적 분석

DC Field Value Language
dc.contributor.advisor조, 경기-
dc.contributor.author김, 재호-
dc.date.accessioned2011-03-17T01:31:15Z-
dc.date.available2011-03-17T01:31:15Z-
dc.date.issued2010-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/1774-
dc.description.tableofcontents"TABLE OF CONTENTS



ABSTRACT ⅰ

TABLE OF CONTENTS ⅲ

LIST OF FIGURES ⅴ

ABBREVIATION ⅶ

Ⅰ. INTRODUCTION 1

Ⅱ. MATERIALS AND METHODS 3

1. Cell culture 3

2. In vivo protocol of experimental tumor models 3

3. In vitro and in vivo cell proliferation assays 4

4. In vivo analysis of tumor-tropism of human neural stem cells 5

5. X-gal stain 6

6. Cell count and unbiased stereology in a tumor region of rats 7

7 .Cell count and unbiased stereology in a entire brain of rats 8

8. Labeling of F3 Cells with 5-bromo-2-deoxyuridine 8

9. Hematoxylin and Eosin stain 9

10. Beta-galactosidase immunofluoresecence 9

11. Statistical Analysis 10

Ⅲ. RESULTS 11

1. Tumor-tropism pattern of NSCs 11

2. Migration rate of NSCs 19

3. NSC migration studied by stereology 23

4. Histological analysis 28

5. Proliferation of NSCs in vitro & in vivo 32

Ⅳ. DISCUSSION 37

Ⅴ. CONCLUSION 43

RFERENCES 45

국문요약 58

"
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dc.language.isoko-
dc.title뇌종양 동물모델에서의 인간신경줄기세포주의 종양으로의 특이적 이주에 관한 입체적 분석-
dc.typeThesis-
dc.identifier.urlhttp://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010367-
dc.description.degreeDoctor-
dc.contributor.department대학원 의학과-
dc.contributor.affiliatedAuthor김, 재호-
dc.date.awarded2010-
dc.type.localTheses-
dc.citation.date2010-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
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