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Bone regeneration by means of a three-dimensional printed scaffold in a rat cranial defect

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dc.contributor.authorKwon, DY-
dc.contributor.authorPark, JH-
dc.contributor.authorJang, SH-
dc.contributor.authorPark, JY-
dc.contributor.authorJang, JW-
dc.contributor.authorMin, BH-
dc.contributor.authorKim, WD-
dc.contributor.authorLee, HB-
dc.contributor.authorLee, J-
dc.contributor.authorKim, MS-
dc.date.accessioned2020-01-09T06:41:19Z-
dc.date.available2020-01-09T06:41:19Z-
dc.date.issued2018-
dc.identifier.issn1932-6254-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/17963-
dc.description.abstractRecently, computer-designed three-dimensional (3D) printing techniques have emerged as an active research area with almost unlimited possibilities. In this study, we used a computer-designed 3D scaffold to drive new bone formation in a bone defect. Poly-L-lactide (PLLA) and bioactive β-tricalcium phosphate (TCP) were simply mixed to prepare ink. PLLA + TCP showed good printability from the micronozzle and solidification within few seconds, indicating that it was indeed printable ink for layer-by-layer printing. In the images, TCP on the surface of (and/or inside) PLLA in the printed PLLA + TCP scaffold looked dispersed. MG-63 cells (human osteoblastoma) adhered to and proliferated well on the printed PLLA + TCP scaffold. To assess new bone formation in vivo, the printed PLLA + TCP scaffold was implanted into a full-thickness cranial bone defect in rats. The new bone formation was monitored by microcomputed tomography and histological analysis of the in vivo PLLA + TCP scaffold with or without MG-63 cells. The bone defect was gradually spontaneously replaced with new bone tissues when we used both bioactive TCP and MG-63 cells in the PLLA scaffold. Bone formation driven by the PLLA + TCP30 scaffold with MG-63 cells was significantly greater than that in other experimental groups. Furthermore, the PLLA + TCP scaffold gradually degraded and matched well the extent of the gradual new bone formation on microcomputed tomography. In conclusion, the printed PLLA + TCP scaffold effectively supports new bone formation in a cranial bone defect.-
dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHBone Regeneration-
dc.subject.MESHCell Adhesion-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCell Proliferation-
dc.subject.MESHFluorescence-
dc.subject.MESHHumans-
dc.subject.MESHOsteogenesis-
dc.subject.MESHPolyesters-
dc.subject.MESHPrinting, Three-Dimensional-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHSkull-
dc.subject.MESHTissue Engineering-
dc.subject.MESHTissue Scaffolds-
dc.subject.MESHX-Ray Microtomography-
dc.titleBone regeneration by means of a three-dimensional printed scaffold in a rat cranial defect-
dc.typeArticle-
dc.identifier.pmid28763610-
dc.subject.keyword3D printing-
dc.subject.keywordbone regeneration-
dc.subject.keywordimaging-
dc.subject.keywordink-
dc.subject.keywordneo-bone formation-
dc.subject.keywordprinted scaffold-
dc.contributor.affiliatedAuthor민, 병현-
dc.type.localJournal Papers-
dc.identifier.doi10.1002/term.2532-
dc.citation.titleJournal of tissue engineering and regenerative medicine-
dc.citation.volume12-
dc.citation.number2-
dc.citation.date2018-
dc.citation.startPage516-
dc.citation.endPage528-
dc.identifier.bibliographicCitationJournal of tissue engineering and regenerative medicine, 12(2). : 516-528, 2018-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1932-7005-
dc.relation.journalidJ019326254-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Orthopedic Surgery
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