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Choroidal Thickness Indicates Subclinical Ocular and Systemic Inflammation in Eyes with Behcet Disease without Active Inflammation

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dc.contributor.authorChung, YR-
dc.contributor.authorCho, EH-
dc.contributor.authorJang, S-
dc.contributor.authorLee, SY-
dc.contributor.authorLee, ES-
dc.contributor.authorLee, K-
dc.date.accessioned2020-01-09T06:41:20Z-
dc.date.available2020-01-09T06:41:20Z-
dc.date.issued2018-
dc.identifier.issn1011-8942-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/17968-
dc.description.abstractPURPOSE: To investigate whether subfoveal choroidal thickness, measured using enhanced depth imaging optical coherence tomography (EDI-OCT), is an indicator of subclinical ocular or systemic inflammation in eyes with Behçet disease (BD) without active ocular inflammation.
METHODS: A retrospective analysis was used to examine clinical features of non-uveitic patients with BD (NUBD group), patients with a previous history of Behçet uveitis in an inactive state (IUBD group), and healthy controls were evaluated from October 2014 to September 2015. Subfoveal choroidal thickness was measured using EDI-OCT.
RESULTS: The NUBD group included 46 eyes in 24 patients; the IUBD group included 16 eyes in 11 patients; and the control group included 35 eyes in 23 individuals. The mean subfoveal choroidal thicknesses differed significantly among these groups. Choroidal thickness was significantly greater in the NUBD (310.5 ± 81.0 μm) than in the IUBD (263.1 ± 56.6 μm, p = 0.013) and control (256.9 ± 67.9 μm, p = 0.002) groups. The disease activity score was significantly higher in the NUBD than in the IUBD group (p < 0.001), while the use of cyclosporine was significantly associated with choroidal thickness in eyes with NUBD (p = 0.039).
CONCLUSIONS: Subfoveal choroidal thickness, as measured by EDI-OCT, may be a clinical indicator of subclinical ocular inflammation and systemic inflammation in BD patients without active ocular inflammation.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHBehcet Syndrome-
dc.subject.MESHChoroid-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInflammation-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOrgan Size-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTomography, Optical Coherence-
dc.subject.MESHUveitis, Anterior-
dc.subject.MESHUveitis, Posterior-
dc.titleChoroidal Thickness Indicates Subclinical Ocular and Systemic Inflammation in Eyes with Behcet Disease without Active Inflammation-
dc.typeArticle-
dc.identifier.pmid30091307-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085188/-
dc.subject.keywordBehcet syndrome-
dc.subject.keywordChoroidal thickness-
dc.subject.keywordInflammation-
dc.contributor.affiliatedAuthor정, 유리-
dc.contributor.affiliatedAuthor이, 은소-
dc.contributor.affiliatedAuthor이, 기황-
dc.type.localJournal Papers-
dc.identifier.doi10.3341/kjo.2017.0139-
dc.citation.titleKorean journal of ophthalmology : KJO-
dc.citation.volume32-
dc.citation.number4-
dc.citation.date2018-
dc.citation.startPage290-
dc.citation.endPage295-
dc.identifier.bibliographicCitationKorean journal of ophthalmology : KJO, 32(4). : 290-295, 2018-
dc.identifier.eissn2092-9382-
dc.relation.journalidJ010118942-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Ophthalmology
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
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