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Neuroprotective Effects of Schisandra chinensis and Ribes fasciculatum Extract on Hydrogen Peroxide-Mediated Oxidative Stress in Neuroblastic SH-SY5Y Cell Line

Other Title
과산화수소로 유도된 SH-SY5Y 신경세포 사멸에 대한 오미자·칠해목 추출혼합물의 보호효과
Authors
Park, EK; Han, KH; Lee, SH; Kim, NK; Bae, MH; Seo, YH; Yong, YJ; Jeong, SY; Choi, CW
Citation
The Korean Journal of Food And Nutrition, 31(6):865-872, 2018
Journal Title
The Korean Journal of Food And Nutrition; 한국식품영양학회지
ISSN
1225-43392287-4992
Abstract
In neuronal cell deaths, oxidative stress is normally implicated with a most of these deaths occurring in neurodegenerative disorders such as the Alzheimer's and Parkinson's diseases. In this study, the neuroprotective effects of Schisandra chinensis (SC) and Ribes fasciculatum (RF) extracts on hydrogen peroxide (H2O2)-induced oxidative stress in neuroblastic cell line were investigated. For an hour, hydrogen peroxide of 100 μM concentration, was induced on neuroblastic cells, causing apoptic cell death. For the neuroprotection, a sample of neuroblastic cells had been pre-treated with SC and RF extracts for 24 hours before application of the hydrogen peroxide. No neurotoxic effects were observed in the cells that had been treated by SC and RF. This prove that the treatment of SC and RF extract prevented apoptotic cell death of neuroblastic cell line exposed to oxidative injury. In addition, applying both SC and RF extracts at a 7:3 ratio increased the neuronal cell survival rate, compared to individual treatments of SC and RF extract. This study suggests that SC and RF extracts may be potential therapeutic agents for the prevention of neuronal cell death.
Keywords
Schisandra chinensis Ribes fasciculatum neuronal cell death neuroprotection oxidative stress
DOI
10.9799/ksfan.2018.31.6.865
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Genetics
AJOU Authors
박, 은국정, 선용
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