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Interleukin-10 endogenously expressed in microglia prevents lipopolysaccharide-induced neurodegeneration in the rat cerebral cortex in vivo.

DC Field Value Language
dc.contributor.authorPark, KW-
dc.contributor.authorLee, HG-
dc.contributor.authorJin, BK-
dc.contributor.authorLee, YB-
dc.date.accessioned2011-03-17T05:39:35Z-
dc.date.available2011-03-17T05:39:35Z-
dc.date.issued2007-
dc.identifier.issn1226-3613-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/1799-
dc.description.abstractA degree of brain inflammation is required for repair of damaged tissue, but excessive inflammation causes neuronal cell death. Here, we observe that IL-10 is expressed in LPS-injected rat cerebral cortex, contributing to neuronal survival. Cells immunopositive for IL-10 were detected as early as 8 h post-injection and persisted for up to 3 d, in parallel with the expression of IL-1beta, TNF-alpha, and iNOS. Double immunofluorescence staining showed that IL-10 expression was localized mainly in activated microglia. Next, we examined the neuroprotective effects of IL-10 using IL-10 neutralizing antibody (IL-10NA). Blockade of IL-10 action caused a significant loss of neurons both 3 d and 7 d after LPS injection. Further, the induction of mRNA species encoding IL-1beta, TNF-alpha, and iNOS, reactive oxygen species (ROS) production, and NADPH oxidase activation, increased after co-injection of LPS and IL-10NA, compared to the levels seen after injection of LPS alone. Taken together, these results clearly suggest that LPS-induced endogenous expression of IL-10 in microglia contributes to neuronal survival by inhibiting brain inflammation.-
dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHCerebral Cortex-
dc.subject.MESHFluorescent Antibody Technique-
dc.subject.MESHInterleukin-10-
dc.subject.MESHLipopolysaccharides-
dc.subject.MESHMicroglia-
dc.subject.MESHNerve Degeneration-
dc.subject.MESHNeurons-
dc.subject.MESHNitric Oxide Synthase-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReactive Oxygen Species-
dc.titleInterleukin-10 endogenously expressed in microglia prevents lipopolysaccharide-induced neurodegeneration in the rat cerebral cortex in vivo.-
dc.typeArticle-
dc.identifier.pmid18160852-
dc.identifier.urlhttp://www.e-emm.org/search_read.htm?page=812&year=2007&vol=39-
dc.contributor.affiliatedAuthor진, 병관-
dc.contributor.affiliatedAuthor이, 용범-
dc.type.localJournal Papers-
dc.identifier.doi10.1038/emm.2007.88-
dc.citation.titleExperimental & molecular medicine-
dc.citation.volume39-
dc.citation.number6-
dc.citation.date2007-
dc.citation.startPage812-
dc.citation.endPage819-
dc.identifier.bibliographicCitationExperimental & molecular medicine, 39(6). : 812-819, 2007-
dc.identifier.eissn2092-6413-
dc.relation.journalidJ012263613-
Appears in Collections:
Journal Papers > Research Organization > Institute for Medical Sciences
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